摘要
目的探讨胰岛素抵抗(IR)在青年(18-44岁)高血压发病中的作用。方法测量278例青年高血压患者(青年高血压组)和220例正常血压青年人(对照组)血压、空腹血糖、空腹血浆胰岛素、血脂等。计算IR指数(IRI)。结果青年高血压组的空腹血糖、空腹血浆胰岛素、IRI、血脂、体质指数、诊室血压、动态血压平均值均明显高于对照组(P<0.05),吸烟、饮酒、睡眠减少、运动减少、家族史以及IRI≥2.69的比例均明显高于对照组(P<0.05)。IRI与诊室平均动脉压呈显著正相关(r=0.174,P<0.01),为青年高血压发病的独立相关因素。结论即使在非糖尿病人群,IR仍是青年高血压发病的独立相关因素。
Objective To explore the role of insulin resistance（IR） in pathogenesis of essential hypertension in the patients aged 18-44 years old. Methods The resting blood pressure,ambulatory blood pressure monitoring,metabolic parameters and homeostasis model assessmemt for IR（IRI） were measured in 278 youth people with hypertension（group A） and 220 young adults with normal blood pressure（group B）. Results Fasting blood glucose,plasma insulin,IRI,mean value of resting blood pressure and ambulatory blood pressure were significantly higher in group A than those in group B（P〈0.05）.Smoking,drinking,less sleeping,less exercise,family history of hypertension, and IRI≥2.69 were more commom in group A than those in group B（P〈0.05）.Multivariate regression analysis revealed that IRI was positively correlated with mean resting blood pressure（r=0.174,P〈0.01）. Conclusion IR is an independent risk factor for hypertension in the youth without diabetes.
出处
《江苏医药》
CAS
北大核心
2013年第2期156-158,共3页
Jiangsu Medical Journal
基金
苏州市科技发展计划指导项目(SYSD2010128)
苏州市科教兴卫计划项目(kjxw2011011)
关键词
胰岛素抵抗
原发性高血压
Insulin resistance
Essential hypertension
