摘要
目的:观察奥美沙坦联合胺碘酮治疗阵发性心房颤动的临床疗效。方法:60例阵发性心房颤动患者随机分为治疗组和对照组各30例,治疗组采用奥美沙坦20 mg/d联合胺碘酮200mg/d治疗,对照组采用胺碘酮200 mg/d治疗,疗程15个月。结果:两组窦性心律维持率在治疗后2个月的差异无统计学意义(P>0.05),但治疗组在治疗后4、6、8、10、12、15个月的窦性心律维持率均明显高于对照组(P<0.05)。两组左心房前后径在治疗后2、4、6个月的差异无统计学意义(P>0.05),但治疗组在治疗后8、10、12、15个月的左心房前后径均明显小于对照组(P<0.05)。结论:奥美沙坦联合胺碘酮治疗阵发性心房颤动疗效确切,可有效逆转左心房扩大。
Objective： To observe the clinical efficacy on olmesartan and amiodarone in the treatment of pa- tients with paroxysmal atrial fibrillation. Methods： Sixty paroxysmal atrial fibrillation patients were randomized into treatment group （n = 30） and control group （n = 30）. The patients in the treatment group received olmesartan （20 mg/d） and amiodarone （200 mg/d）. The patients in the control group received amiodarone （200 mg/d）. The treatment period of both groups was 15 months. Results： There was no statistic difference of sinus rhythm mainte- nance in the two groups at the end of 2 months （ P 〉 0.05 ）. While the sinus rhythm maintenance ratio of the treat- ment group in 4, 6, 8, 10, 12, 15 months after treatment is greater than that of the control group （P 〈0. 05）. There was no statistic difference of left atrial anteroposterior in the two groups in 2, 4, 6 months after treatment （P 〉0. 05）. While the left atrial anteroposterior of the treatment group in the treatment of 8, 10, 12, 15 months is shorter than that of the control group （P 〈 0. 05 ）. Conclusion： Combination of olmesartan and amiodarone can significantly reduce the occurrence of atrial fibrillation compared with amiodarone alone, and can revert left atrial enlargement.
出处
《新医学》
2012年第12期838-840,共3页
Journal of New Medicine
关键词
胺碘酮
奥美沙坦
阵发性心房颤动
窦性心律
左心房前后径
Amiodarone
Olmesartan
Paroxysmal atrial fibrillation
Sinus rhythm
Left atrial anteroposterior
