摘要
对白血病患儿体内血清锌、血清铜浓度以及血清铜 /锌比值作了初步的观测。在 4 1例白血病患儿和 3 3例正常对照儿童中 ,观察到在明确诊断化疗前 ,4 1例白血病患儿中有 2 0例患儿的血清锌浓度低于正常低限 ,他们的平均血清锌浓度为 1 2 3± 3 4 μmol/L ,明显低于对照组 1 8 3± 4 0 μmol/L。白血病患儿的血清铜 /锌比值为 1 4 0± 0 3 8,明显高于正常儿童 1 1 9± 0 2 5。经治疗后 ,有 1 2例患儿获缓解并继续随访至发病后 6～ 8周 ,平均血清锌浓度由 1 1 4± 2 2 μmol/L,提高到 1 3 7± 2 1 μmol/L ,血清铜 /锌比值由 1 51± 0 3 6,下降到 1 2 9± 0 2 3。说明白血病患儿体内存在着锌代谢的异常。
The serum zinc concentration and copper/zinc ratio of 41 children with acute leukemia a and 33 control subjects were observed. The results showed that at the onset of this disease, the serum zinc concentration of 20 patients was lower than the limit of the normal value, and the mean concentration of serum zinc in patients was significantly lower than that of the control group. The copper/zinc ratio was significantly higher than that of the control group. After treatment,serum zinc concentration increased and the copper/zinc ratio decreased in the patients group,gradually returned to normal. This observation showed that there were zinc metabolism disorders in children with acute leukemia.
出处
《广东微量元素科学》
CAS
2000年第3期33-36,共4页
Trace Elements Science
