摘要
目的探讨无创通气救治慢性阻塞性肺疾病急性加重(AECOPD)并肺性脑病的临床价值。方法 52例AECOPD并肺性脑病患者被随机分为两组,对照组(26例)给予药物、氧疗等常规治疗,治疗组(26例)在常规治疗的基础上加用BiPAP无创通气。结果治疗组治疗后2h,PaO2即有显著上升(与治疗前比较P<0.05)。治疗后24hpH值上升、PaCO2下降,与治疗前比较均有显著性差异(P<0.05)。对照组治疗前后PaCO2,pH值均无显著性差异(P>0.05),治疗后24hPaO2有明显上升(与治疗前比较P<0.05)。治疗组气管插管率、病死率均明显低于对照组(P<0.05),治疗组有效率明显高于对照组(P<0.05)。结论对AECOPD并肺性脑病患者,BiPAP无创通气是一种有效的治疗手段,可以较快地改善临床症状和动脉血气,减少气管插管率和死亡率。
Objective To explore the clinical value on non-invasive ventilation therapy for acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary encephalopathy.Methods 52 cases of acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary encephalopathy were randomly divided two groups control group（n=26） with conventional therapy and experiment group（n=26） with non-invasive BiPAP ventilation based on conventional therapy.Results In the BiPAP group,there was a siginificant improvement of PaO2 at 2 hours after the therapy.PaCO2 and pH were also improved obviously at 24 hours after the therapy compared with baseline（P0.05）.In the conventional therapy group.PaCO2 and pH didnot improve siginifieantly at 24 hours after the therapy（P0.05）.There was a siginifleant improvement of PaO2 at 24 hours after the therapy（P0.05）.The rate of death and endotracheal intubation in the BiPAP group was markedly Lower than that in the conventional therapy group（P0.05）.The effective rate in the BiPAP group was obviously higher than that in the conventional therapy group（P0.05）.Conclusion Noninvasive BiPAP ventilation is effective for acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary encephalopathy.It can improve artery blood gases and clinical symptoms rapidly,decrease the rate of endotracheal intubation and of death.
出处
《中国实用医药》
2012年第36期10-11,共2页
China Practical Medicine
