期刊文献+

Peutz-Jeghers综合征小肠息肉的诊治技术现状和药物治疗进展 被引量:10

Detection and treatment of small-bowel polyps in Peutz-Jeghers syndrome
暂未订购
导出
摘要 Peutz-Jeghers综合征具有特征性的皮肤、黏膜黑斑和胃肠道多发息肉,本征的息肉最常出现在小肠,可导致消化道出血、肠梗阻、肠套叠、癌变等并发症,常需手术治疗。对小肠息肉的及时检出和治疗,不仅有利于减少各种并发症,而且可以减少手术干预。本文将对Peutz-Jeghers综合征小肠息肉的各种检测和治疗方法的优劣性及最新的药物治疗进行阐述。 Peutz-Jeghers syndrome (PJS) features mueoeutaneous pigmentation and gastrointestinal tract polyps. Polyps are most commonly found in the small-bowel and may cause bleeding, intussuseeptions, obstruction and malignancy, many patienls require laparotomy. Early detection and measurement of small-bowel polyps will benefit for reducing the compliealions and frequency of laparotomy. This review is to assess the value of the different approach of detection and treatment for small-bowel polyps in patients with PJS.
出处 《胃肠病学和肝病学杂志》 CAS 2013年第2期185-191,共7页 Chinese Journal of Gastroenterology and Hepatology
关键词 PEUTZ-JEGHERS综合征 小肠 息肉 检测 治疗 Peutz-Jeghers syndrome Small-bowel Polyps Detection Treatment
  • 相关文献

参考文献28

  • 1顾国利,魏学明,徐丽梅,王石林.Peutz-Jeghers综合征预防性治疗的研究[J].胃肠病学和肝病学杂志,2012,21(4):380-383. 被引量:26
  • 2Pennazio M,Rossini FP. Small bowel polyps in Peutz-Jeghers syndrome:management by combined push enteroscopy and intraoperative enteroscopy[J].Gastrointestinal Endoscopy,2000,(03):304-308.
  • 3Sakamoto H,Yamamoto H,Hayashi Y. Nonsurgical management of small-bowel polyps in Peutz-Jeghers syndrome with extensive polypectomy by using double-balloon endoscopy[J].Gastrointestinal Endoscopy,2011,(02):328-333.
  • 4Oncel M,Remzi FH,Church JM. Benefits of 'clean sweep' in Peutz-Jeghers patients[J].Colorectal Disease,2004,(05):332-335.
  • 5Edwards DP,Khosraviani K,Stafferton R. Long-term results of polyp clearance by intraoperative enteroscopy in the Peutz-Jeghers syndrome[J].Diseases of the Colon & Rectum,2003,(01):48-50.
  • 6Soares J,Lopes L,Vilas Boas G. Wireless capsule endoscopy for evaluation of phenotypic expression of small-bowel polyps in patients with Peutz-Jeghers syndrome and in symptomatic first-degree relatives[J].Endoscopy,2004,(12):1060-1066.
  • 7Ohmiya N,Nakamura M,Takenaka H. Management of small-bowel polyps in Peutz-Jeghers syndrome by using enteroclysis,double-balloon enteroscopy,and videocapsule endoscopy[J].Gastrointestinal Endoscopy,2010,(06):1209-1216.
  • 8Utsunomiya J,Gocho H,Miyanaga T. Peutz-Jeghers syndrome:its natural course and management[J].JOHNS HOPKINS MEDICAL JOURNAL,1975,(02):71-82.
  • 9van Lier MG,Mathus-Vliegen EM,Wagner A. High cumulative risk of intussusception in patients with Peutz-Jeghers syndrome:time to update surveillance guidelines[J].American Journal of Gastroenterology,2011,(05):940-945.
  • 10McGarrity TJ,Peiffer LP,Billingsley ML. Overexpression of epidermal growth factor receptor in Peutz-Jeghers syndrome[J].Digestive Diseases and Sciences,1999,(06):1136-1141.

二级参考文献22

  • 1沈红梅,程涛,乔传卓,苏中武,李承祜.乌梅的体外抗肿瘤活性及免疫调节作用初探[J].中国中药杂志,1995,20(6):365-368. 被引量:45
  • 2杨澍.乌梅祛息肉妙用四则[J].中外健康文摘·医药学刊,2008,:92-92.
  • 3McGarrity TJ, Peiffer LP, Amos CI, et al. Overexpression of cyclooxy-genase 2 in hamartomatous polyps of Peutz-Jeghers syndrome [J]. Am J Gastroenterol, 2003, 98(3 ): 671-678.
  • 4Rosner M, Hanneder M, Siegel N, et al. The mTOR pathway and its role in human genetic diseases [ J]. Mutat Res, 2008, 659 (3): 284 -292.
  • 5McGarrity TJ, Peiffer LP, Billingsley ML. Overexpression of epidermal growth factor receptor in Peutz-Jeghers syndrome [ J ]. Dig Dis Sci, 1999, 44(6) : 1136-1141.
  • 6Brugarolas J, Kaelin WG Jr. Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes [J]. Cancer Cell, 2004, 6(1): 7-10.
  • 7Udd L, Katajisto P, Rossi DJ, et al. Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2 [ J ]. Gastroenterology, 2004, 127(4): 1030.1037.
  • 8Shacke!Xord DB, Vasquez DS, Corbell J, et al. roTOR and HIF- lalpha-mediated tumor metabolism in an LKB1 mouse model of Peutz- Jeghers syndrome [J]. Proc Natl Acad Sci U S A, 2009, 106(27) : 11137-11142.
  • 9Kuwada SK, Burt R. A rationale for mTOR inhibitors as chemopre- vention agents in Peutz-Jeghers syndrome [ J]. Fam Cancer, 2011, 10(3) : 469-472.
  • 10Kliimpen HJ, Queiroz KC, Spek CA, et al. roTOR inhibitor treatment of pancreatic cancer in a patient with Peutz-Jeghers syndrome [ J]. J C|in Oncol, 2011, 29(6) : e150- e153.

共引文献25

同被引文献141

  • 1Odul Egritas Gurkan,Tarkan Karakan,Ibrahim Dogan,Buket Dalgic,Selahattin Unal.Comparison of double balloon enteroscopy in adults and children[J].World Journal of Gastroenterology,2013,19(29):4726-4731. 被引量:11
  • 2于恩达.家族性腺瘤性息肉病诊治进展[J].中国实用外科杂志,2005,25(4):249-251. 被引量:17
  • 3戴益琛,宋于刚,肖冰,张亚历,智发朝,姜泊,周殿元.黑斑息肉综合征52例内镜与外科治疗[J].临床内科杂志,2005,22(7):455-457. 被引量:14
  • 4Mozaffar M,Sobhiyeh M R,Hasani M,et al. Peutz - Jeghers syndromewithout mucocutaneous pigmentation:a case report[ J]. GastroenterolHepatol Bed Bench,2012,5(3) : 169-173.
  • 5Chen X D I,Yu Y Y, Yang L,et al. Duodenal intussusception due toa giant neuroendocrine carcinoma in a patient with Peutz - Jegherssyndrome : case report and systematic review [ J ] . Eur J GastroenterolHepatol,2012,24(6) :722-726.
  • 6Ali Ozer, Pinar Sarkut, Ersin Ozturk, et al. Jejunoduodenal intussus-ception caused by a solitary polyp in a woman with Peutz - Jegherssyndrome;a case report[ J]. J Med Case Rep,2014,8:13.
  • 7Banno K I,Kisu I,Yanokura M, et al. Hereditary gynecologicaltumors associated with Peutz - Jeghers syndrome ( Review ) [ J]. On-col Lett,2013,6(5) :1184-1188.
  • 8Lim W,Olschwang S,Keller J J,et al. Relative frequency and mor-phology of cancers in STK11 mutation carriers[ J]. Gastroenterology,2004,126:1788-1794.
  • 9Hearle N,Schumacher V,Menko F H,et al. Frequency and spectrumof cancers in the Peutz - Jeghers syndrome [ J ]. Clin Cancer Res,2006,12:3209-3215.
  • 10Bhattacharya S I,Mahapatra S R,Nangalia R. Melaena with Peutz -Jeghers syndrome:a case repor[ J]. J Med Case Rep,2010,8(4):44.

引证文献10

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部