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乙基-2-氟-3,6-二氧苯甲酰基-4-氧-(2,3,4,6-四氧乙酰基-β-D-半乳糖基)-β-D-甘露糖的合成

Synthesis of ethyl-2-fluoro-3,6-di-O-benzoyl-4-O-(2,3,4,6-tetra-O-acetyl-β-D-galacto-pyranosyl)-β-D-mannopyranoside
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摘要 以D-甘露糖和D-半乳糖为起始原料,介绍了一种经过系列反应合成乙基-2-氟-3,6-二氧苯甲酰基-4-氧-(2,3,4,6-四氧乙酰基-β-D-半乳糖基)-β-D-甘露糖的新方法,其结构经气相-质谱(LC-MS)、1H核磁共振(1H NMR)和19F核磁共振(19F NMR)确证。合成的乙基-2-氧三氟甲磺酸基-3,6-二氧苯甲酰基-4-氧(2,3,4,6-四氧乙酰基-β-D-半乳糖基)-β-D-甘露糖是新型糖代谢PET试剂乙基-2-[18F]氟-4-O-(β-D-半乳糖基)-β-D-甘露糖(C2H5-18FDL)的关键前体化合物。 An important precursor ethyl-2-trifluoromethanesulfony1-3,6-di-O-benzoyl-4-O- （ 2,3,4,6-tetra- O-acetyl-β-D-galacto-pyranosyl）-β-D-mannopyranoside was synthesized as a new PET imaging material ethyl-2-deoxy-2-[ 18 F ] fluoro-4-O-β-D-galactopyranosyl-β-D-glucopyranoside （ C2 Hs-[ 18 F ] FDL ）. The precursor was prepared from commercially available D-mannose and D-galactose with a series of reactions. A novel synthetic method for ethyl-2-deoxy-2-fluoro-4-O-β-D-galactopyranosyl-β-D- glucopyranoside was given. The structure was confirmed by LC-MS,1H NMR and 19F NMR.
作者 王海东 陈建军 张思伟 陈桂明 桂媛 徐志宏 姚成
机构地区 南京工业大学理学院 常熟华益化工有限公司
出处 《南京工业大学学报（自然科学版）》 CAS 北大核心 2013年第1期114-120,共7页 Journal of Nanjing Tech University(Natural Science Edition)
关键词 PET试剂 C2H5-18FDL 前体化合物 合成 PET reagent C2 H5-18FDL precursor synthesis
分类号 O629.13 [理学—有机化学]
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参考文献8

  • 1Poston G J,Williamson R C. Causes,diagnosis,and management of exocrine pancreatic cancer[J].Comprehensive Therapy,1990.36-42.
  • 2Ying Y,Ghosh P,Guo L W. Synthesis and ex vivo autoradiographic evaluation of ethyl-β-D-galactopyranosyl-(1,4')-2'-deoxy-2'-[18 F]fluoro-β-D-glucopyranoside-a novel radioligand for lactose-binding protein:implications for early detection of pancreatic carcinomas with PET[J].Molecular Imaging and Biology,2011,(03):536-546.
  • 3Yun M,Chun K H,Shin J E. Synthesis of ethyl-D-galactopyranosyl-(1-4)-2-deox-2-fluoro-b-D-glucopyranoside[J].Bulletin of the Korean Chemical Society,2002.177-178.
  • 4Crich D,Li W,Li H. Direct chemical synthesis of the betaman-nans:linear and block syntheses of the alternating beta-(1→3)-beta-(1→ 4)-mannan common to Rhodotorula glutinis,Rhodotorula mucilaginosa,and Leptospira biflexa[J].Journal of the American Chemical Society,2004,(46):15081-15086.
  • 5Oshitari T,Shibasaki M,Yoshizawa T. Synthesis of 2-O-(3-O-carbamoyl-α-D-mannopyranosyl)-L-gulopyranose:sugar moiety of antitumor antibiotic bleomycin[J].Tetrahedron,1997.10993-11006.
  • 6Crich D,Banerjee A,Yao Q J. Direct chemical synthesis of the β-d-mannans:theβ-(1→2) andβ-(1→4) series[J].Journal of the American Chemical Society,2004,(45):14930-14934.
  • 7Crich D,Banerjee A,Li W. Improved synthesis of 1-benzenesulfinyl piperidine and analogs for the activation of thioglycosides in conjunction with trifluoromethanesulfonic anhydride[J].Journal of Carbohydrate Chemistry,2005,(4/5/6):415-424.
  • 8Crich D,Smith M,Yao Q J. 2,4,6-tri-tert-butylpyrimidine (TTBP):a cost effective,readily available alternative to the hindered base 2,6-di-tert-butylpyridine and its 4-substituted derivatives in glycosylation and other reactions[J].Synthesis-Stuttgart,2001,(02):323-326.
南京工业大学学报（自然科学版）
2013年 第1期

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