摘要
目的:探讨2型糖尿病(T 2DM)患者血清尿酸(SUA)水平与颈动脉内膜中层厚度(IMT)的关系。方法:2011年8月～2012年6月内分泌科住院的157例T2DM患者,分为高血尿酸组(68例)及正常血尿酸组(89例)。记录患者身高、体重、腰围和臀围,测定空腹血糖(FBG)、血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDLC)、空腹胰岛素(FINS)、IMT,并计算相应的体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR)。结果:高血尿酸组BMI、WHR、FINS、HOMA-IR、LDL-C、TG、IMT较正常血尿酸组升高(P<0.05),而FBG、TC、HDL-C两组差异无显著性(P>0.05)。结论:2型糖尿病高血尿酸组更易出现血脂异常、胰岛素抵抗及动脉粥样硬化。
Objective：To investigate the relationship between serum level of uric acid （SUA） and carotid artery intima - media thickness （IMT） in type 2 diabetes mellitus（T2DM）. Methods：According to level of SUA, a total of 157 patients with T2DM visited in our department of endocrinology from August 2011 to Jun 2012 were divided into high SUA group （ n = 68 ） and normal SUA group （ n = 89） . Their body height,weight ,waist,hip were recorded ,the levels of fasting blood glucose （FBG） ,serum total cholesterol （TC） ,serum triglyceride（TG）,serum high density lipoprotein （HDL -C）,serum low density lipoprotein （LDL -C） ,fasting serum insulin （FINS）and IMT were determined, body mass index （BMI）, the waist to hip ratio（WHR） and insulin resistance index （ HOMA - IR） were calculated. Results： The levels of BMI, WHR, FINS, HOMA -IR, LDL - C, TG and IMT increased significantly in high SUA group compared with normal SUA group （ P 〈 0.05 ）, the levels of FBG, TC and HDL - C had no statistical significance between two groups （P 〉 0.05 ）. Conclusions： High SUA group in T2DM patients had remarkable dyslipidemia,insulin resistance and atherosclerosis.
出处
《中国民康医学》
2013年第1期29-31,共3页
Medical Journal of Chinese People’s Health
基金
2011年广东省科技计划项目(课题编号:2011B031800273)
