摘要
目的探讨联合检测血脂各组分对糖尿病并冠心病(CHD)预测的意义。方法选取2型糖尿病并CHD患者64例作为观察组,另选取单纯2型糖尿病患者32例作为对照组,检测2组总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白(a)[LP(a)]指标,并对2组进行Gensini评分。结果观察组TC、TG、LDL-C、ApoB、LP(a)水平及Gensini评分均高于对照组,HDL-C、ApoA1、ApoA1/ApoB比值均低于对照组,差异均有统计学意义(P<0.05或P<0.01)。观察组各组分与Gensini积分进行相关分析示除ApoA1、HDL-C与其呈负相关,其余指标[TC、TG、LDL-C、Lp(a)、ApoB]均与其呈正相关;观察组各血脂异常中ApoB及LDL-C异常所占比重较大。结论糖尿病并CHD患者脂代谢紊乱明显,血脂各组分与糖尿病并CHD有密切关系,尤其与ApoB及LDL-C关系密切。
Objective To discuss the value of combined detection of lipids various components to predicting type 2 diabetes with coronary heart disease（CHD）.Methods 64 cases patients with type 2 diabetes combined CHD were set as observation group,and 32 cases patients with simple type 2 diabetes were set as control group.Cholesterol（TC）,triacylglycerol（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,apolipoprotein A1（ApoA1）,apolipoprotein B（ApoB）,lipoprotein（a） of 2 groups were detected,and Gensini score were used.Results The level of TC、TG、LDL-C、ApoB、Lp（a）and score of Gensini in observation group were higher than those of control group,and the level of HDL-C、ApoA1 and ApoA1/ApoB were lower than those of control group,the difference were statistically significant（P〈0.05 or P〈0.01）.The correlation analysis showed that ApoA1、HDL-C in observation group were negative correlation with Gensini score,but positive correlation with TC 、TG、LDL-C、Lp（a）、ApoB.ApoB and LDL-C accounted for the largest percentage in all of the anomaly blood lipid indicators of observation group.Conclusion Lipid metabolism of patients with type 2 diabetes combined CHD has an obvious disorder,lipids various components are closely related with type 2 diabetes combined CHD,especially for ApoB and LDL-C.
出处
《临床合理用药杂志》
2013年第4期13-14,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
糖尿病
2型
冠心病
血脂
Diabetes
type 2
Coronary heart disease
Lipids
