摘要
目的观察替吉奥治疗老年或功能状态评分差晚期结直肠癌患者的疗效。方法选择2007年1月—2011年1月我科收治的晚期结直肠癌患者46例,所有患者口服替吉奥30 mg/m2,2次/d,连续治疗14 d后休息7 d,21 d为1个化疗周期,至少治疗2个化疗周期。治疗完成后评价患者疗效并通过电话形式对患者进行随访,采用Kap-lan-Meier法计算患者中位疾病进展时间(TTP)、中位总生存时间(OS)、1年生存率及其95%CI。结果 46例患者中完全缓解0例,部分缓解12例,病情稳定28例,疾病进展6例;客观反应率为26%,疾病控制率为87%;中位TTP为5.3个月〔95%CI(3.1,8.9)〕;中位OS为8.6个月〔95%CI(5.1,11.3)〕;1年生存率为26.1%〔95%CI(12.2%,45.3%)〕。46例患者中有1例患者出现Ⅳ级外周血中性粒细胞减少并伴有发热,25例患者出现Ⅰ～Ⅲ级血小板计数减少,其他患者均出现不同程度的贫血、恶心或呕吐、疲劳、厌食、脱发等,未影响治疗;无因毒副作用退出或终止治疗者,无治疗相关死亡者。结论替吉奥治疗老年或功能状态评分差的晚期结直肠癌患者疗效肯定,安全可靠,服用方便,患者耐受性较好,值得推广应用。
Objective To investigate the efficacy of S-1 in patients with elderly or poor functional status score advanced colorectal cancer. Methods 46 patients with advanced colorectal cancer admitted to our department from January 2007 to January 2011 were selected.All the patients were given 30 mg/m2 S-1 per os twice daily for 14 consecutive days followed by 7 days of no medicine.The patients were given at least two cycles of treatment with each cycle 21 days.After treatment,the efficacy was assessed and the patients were followed up by telephone.Kaplan-Meier method was used to calculate median TTP,OS,one-year survival rate and 95%CI. Results Of the 46 patients,no case had complete remission,12 cases had partial remission,28 cases had stable disease and 6 cases had progression of disease.The objective response rate was 26% and disease control rate was 87%.The median TTP was 5.3 months（95%CI（3.1,8.9））,the median OS was 8.6 months（95%CI（5.1,11.3））and the one-year survival rate was 26.1%（95%CI（12.2%,45.3%））.One case out of the 46 patients had Ⅳ level neutrophils decrease in peripheral blood accompanied by fever,25 cases had level Ⅰ to Ⅲ thrombocytopenia,and other patients had various levels of anemia,nausea,fatigue,anorexia and hair loss,but did not affect treatment.No case retreated or terminated treatment due to adverse events and no case died during treatment. Conclusion S-1 is effective and safe in the treatment of elderly or poor functional status score advanced colorectal cancer with good tolerance and convenient intake,and it should be promoted in clinic.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第3期305-307,共3页
Chinese General Practice
