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血清人附睾蛋白4检测在子宫内膜癌诊断中的价值

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摘要 评价血清人附睾蛋白4(human epididymis protein 4,HE4)在子宫内膜癌诊断中的应用价值。采用酶联免疫吸附(ELISA)方法检测40例子宫内膜癌患者,同期就诊60例子宫内膜增生患者及70例健康体检者的血清HE4水平。子宫内膜癌组、子宫内膜增生组及健康体检组的血清HE4水平分别为163.26±29.88pmol/L、55.46±17.21pmol/L和47.49±9.83pmol/L,3组差异有统计学意义(P<0.05);其中子宫内膜癌组的HE4水平高于子宫内膜增生组及健康体检者,差异有统计学意义(P<0.05);而子宫内膜增生组与健康体检者相比,二者的HE4水平差异无统计学意义(P>0.05)。子宫内膜癌组中,血清HE4水平在肿瘤分期、分化程度方面比较,差异有统计学意义(P<0.05),在年龄、病理类型方面比较,差异无统计学意义(P>0.05)。此外,子宫内膜癌组术后血清中HE4水平明显低于术前,差异有统计学意义(P<0.05)。HE4是子宫内膜癌早期诊断、疗效评价及判断预后的可靠血清学标志物。
作者 孙萍 贺秀芬
出处 《甘肃科技》 2013年第1期119-120,130,共3页 Gansu Science and Technology
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  • 1Ulrich LS. Endometrial cancer,types,prognosis,female hormones and antihormones[J].Climacteric,2011,(04):418-425.
  • 2Montagnana M,Danese E,Giudici S. HE4 in ovarian cancer:from discovery to clinical application[J].Advances in Clinical Chemistry,2011.1-20.
  • 3Kirchhoff C,Habben I,Ivell R. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors[J].Biology of Reproduction,1991,(02):350-357.
  • 4Bingle L,Singleton V,Bingle CD. The putative ovarian tumour marker gene HE4 (WFDC2),is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms[J].Oncogene,2002,(17):2768-2773.doi:10.1038/sj.onc.1205363.
  • 5Galgano MT,Hampton GM,Frierson HF Jr. Comprehe nsive analysis of HE4 expression in normal and malignant human tissues[J].Modern Pathology,2006,(06):847-853.
  • 6Moore R G,Brown A K,Miller MC. Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus[J].Gynecologic Oncology,2008,(02):196-201.doi:10.1016/j.ygyno.2008.04.002.
  • 7Huhtinen K,Suvitie P,Hiissa J. Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts[J].British Journal of Cancer,2009,(08):1315-1319.

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