摘要
目的观察支原体肺炎(MPP)患儿血清炎性细胞因子(IL-2、IL-6)、免疫球蛋白(Ig)和补体、高敏C-反应蛋白(hs-CRP)水平的变化,并探讨其意义。方法 MPP患儿50例(观察组,其中重症28例、轻症22例),健康儿童42例作为对照组。采用ELISA法检测两组血清IL-2、IL-6,用血浆蛋白分析仪速率散射比浊法检测hs-CRP、Ig和补体(C3、C4)水平。结果与对照组比较,观察组急性期IL-2、IgA水平降低,IL-6、hs-CRP、IgM、IgG、C3、C4水平升高(P<0.05或0.01);恢复期IL-2水平降低,hs-CRP、IgG水平升高(P<0.05或0.01)。与恢复期比较,观察组急性期IL-2水平降低,IL-6、hs-CRP、C3水平升高(P<0.01)。与轻症者比较,重症者IL-2、IgA水平降低,IL-6、hs-CRP、IgM、IgG、C3、C4水平升高(P<0.05或<0.01)。MPP患儿血清中IL-2与IL-6呈负相关(r=-0.634,P=0.017)。结论 MMP急性期、恢复期或重症、轻症患儿血清炎性细胞因子、Ig、补体、hs-CRP水平升高或降低,联合检测上述指标可及时判定MMP病情程度和预后,有助于指导MP患儿的治疗。
Objective To observe the changes of serum cytokine（IL-2 and IL-6）, imunoglobulin （Ig）, complement, high-sensitivity C-reactive protein （hs-CRP） in children with mycoplasma pneumonia （MPP）and to probe into the clinical significance. Methods 50 children with MPP （the observed group, of whom 28 were severe cases and 22 were mild ca- ses） and 42 healthy children （the matched group）were enrolled, ELISA was used to determine the ordinary pneumonia serum IL-2, IL-6 levels, scattering rate turbidime-tric method was used to determine the contents and composition of hs-CRP, Ig and complement （ C3, C4）. Results Compared with matched group, during the severe period, IL-2 and IgA levels in the observed group decreased, levels of IL-6, hs-CRP, IgM, IgG, C3, C4 increased（P 〈0.05 or 0.01） ; whereas during convalescence period, IL-2 level decreased, levels of hs-CRP, IgG increased（P 〈0.05 or 0.01 ）. Compared with conva- lescence, IL-2 level in the observed group decreased, levels of IL-6, hs-CRP, C3 increased（ P 〈 0.01 ）. Compared with mild cases, levels of IL-2, IgA in severe cases decreased, levels of IL-6, hs-CRP, IgM, IgG, C3, CA increased（P 〈 0.05 or 〈 0.01 ）. IL-6 concentration was negatively correlated with the IL-2 level in MPP patients （ r = - 0. 634, P = 0.017）. Conclusions Serum cytokine, Ig, complement, hs-CRP in children with MPP decrease or increase during severe and con- valescence period or in severe and mild cases ; The detection of these indexes will facilitate determining the state of illness and prognosis and help guide the therapy of MPP.
出处
《山东医药》
CAS
2013年第3期19-21,共3页
Shandong Medical Journal
基金
湖南省标准化战略项目(2011-494)
