摘要
目的:观察慢性心衰患者12周有氧运动和抗心衰药物联合干预前、后红细胞分布宽度(RDW)、心功能及运动能力的变化并探讨RDW与心功能和运动能力的关系。方法:59名心衰患者随机分为运动组(n=35)和对照组(n=24),对照组常规服用抗心衰药物并保持日常生活习惯,运动组在对照组的基础上进行为期12周的有氧运动。实验前、后利用症状限制性运动负荷实验测试运动能力,包括VO2max、最大功率和力竭时间;检测心功能:彩色多普勒超声诊断仪测定左室射血分数(LVEF),利用美国纽约心脏病学会(NYHA)标准对心功能分级;血细胞分析仪测定红细胞计数、血红蛋白、红细胞压积和RDW。结果:偏相关分析显示,RDW与NYHA分级(r=-0.325,P<0.01)、LVEF(r=-0.376,P<0.01)、VO2max(r=-0.427,P<0.01)、最大功率(r=-0.326,P<0.01)和力竭时间(r=-0.278,P<0.05)均呈负相关。实验后,运动组LVEF(P<0.01)、VO2max(P<0.01)、最大功率(P<0.01)和力竭时间(P<0.01)显著性增加,NYHA心功能分级(P<0.01)、安静心率(P<0.05)、RDW(P<0.05)显著性下降;对照组各指标均无显著性变化(均为P>0.05)。结论:1)RDW与慢性心衰患者心功能和运动能力均存在显著负相关关系;2)规律有氧运动和抗心衰药物联合作用可下调慢性心衰患者RDW,提高心功能和运动能力。
Objective： To observe the effects of 12-week aerobic exercise and anti-heart failure drug on red blood cell distribution width （RDW）, cardiac function and exercise capacity of chronic heart failure patients and to explore the relationship of RDW and cardiac function, exer- cise capacity. Methods： Fifty-nine heart failure patients were randomly divided into exercise group （n=35） and control group （n= 24）. Subjects in control group took anti-heart failure medicine and maintained the routine daily life and those in exercise group conducted 12-week aerobic exercise protocol based on control group. Before and after test, exercise capacity indexes including maximal oxygen uptake （VOz max）, maximum power and exhaust time by symptom- limited exercise test ; cardiac function including left ventricular ejection fraction （LVEF） by col- or Doppler ultrasound diagnostic apparatus and cardiac function class by New York Heart As- sociation （NYHA） criterion; red blood cell count, hemoglobin, hematocrit and RDW by blood cytoanalyzer were determined. Results： Partial correlation analysis displayed that RDW nega- tively correlated with NYHA class （ r = - 0. 325, P 〈 0. 01 ）, LVEF （ r = - 0. 376, P 0. 01） , VOz max （r=-0. 427,P〈0.01）,maximum power （r=-0. 326,P〈0.01） and exhaust time （r= -0. 278,P〈0.05）. After test,LVEF （P〈0.01） ,VOzmax （P〈0. 01）, maximum power （P〈0.01） and exhaust time （P〈0.01 ） significantly increased and NYHA class （P〈0.01） ,rest heart rate （P〈0.05） and RDW （P〈2.05） reduced in exercise group compared with pre-test, but all the indexes in control group showed no significantly different （all P〉 0.05）. Conclusion： 1）There existed negative correlation between RDW and cardiac function, as well as RDW and exercise capacity in chronic heart failure patients; 2）Regular aerobic exercise could downregulate RDW, enhance cardiac function and exercise capacity in chron ic heart failure patients.
出处
《中国体育科技》
CSSCI
北大核心
2013年第1期52-56,77,共6页
China Sport Science and Technology
