摘要
目的 研究增殖细胞核抗原 (PCNA)和CD44V6表达与胃癌侵袭转移及预后的关系 ,探讨胃癌组织PCNA和CD44V6表达的相互关系。方法 采用SP免疫组化染色方法 ,检测 90例胃癌组织PCNA和CD44V6的表达情况。结果 胃癌组织PCNA标记指数 (LI)为6 3 83 %± 17 16 % ,CD44V6阳性表达率为 74 4% (6 7 90 ) ;PCNALI和CD44V6表达强度与胃癌淋巴结转移、浸润深度及TNM分期均呈显著正相关 (P <0 .0 5 ) ;PCNALI≥ 5 0 %或CD44V6强阳性表达的胃癌患者术后 1,3 ,5年生存率均显著降低 (P <0 .0 5 ) ;CD44V6阳性表达胃癌组织的PCNALI显著高于CD44V6阴性表达者 (P <0 .0 5 )。结论 PCNA和CD44V6表达与胃癌侵袭转移及预后显著相关 ;
Objective To study the correlation between the expressions of PCNA and CD44V6 with the tumor invasion and metastasis, and prognosis in patients with gastric cancer(GC), and to evaluate the relationship between the expression of PCNA and CD44V6 in GC. Methods The expression of PCNA and CD44V6 was detected in 90 resected GC specimens with strptavidin peroxidase immunohistochemistry method. Results The mean PCNA LI in gastric cancer was 63.85%±17.16%; the positive rate of CD44V6 expression was 74.4%(67/90). The PCNA LI and staining intensity of CD44V6 were significantly correlated with the lymph node metastasis, depth of invasion, and the TNM stage classification of GC(P<0.05). In patients with high PCNA LI(50% or greater) or strong CD44V6 expression, the 1,3,5 years survival rate were significantly decreased(P<0.05). The PCNA LI in patients with positive CD44V6 expression was significant higher than that in patients with negative CD44V6 expression(P<0.05). Conclusions The PCNA and CD44V6 expression are significantly correlated with the invasion and metastasis and patients' prognosis of GC, the expression of CD44V6 may benefit increase in GC cell proliferative activity.
出处
《中国普通外科杂志》
CAS
CSCD
2000年第4期318-320,共3页
China Journal of General Surgery
