摘要
目的 探讨尿激酶型纤溶酶原激活物 (UPA )mRNA表达与胃癌侵袭和转移的关系。方法 采用NorthernBlot技术检测胃癌、近癌旁和远癌胃组织UPAmRNA表达。结果 胃癌、近癌旁和远癌胃组织UPAmRNA表达阳性率分别为 85 % ,31%和 10 %。早期胃癌为阴性表达 ,进展期胃癌呈显著高表达。有浆膜侵袭和淋巴结转移的胃癌呈显著高表达。
Objective To investigate the relationship between the urokinase type plasminogen activator(UPA) mRNA expression with the invasion and metastasis of gastric cancer. Methods UPA mRNA expression in gastric cancer tissue(GCT), tissue near tumor(NT) and tissue far away from tumor(FATT) was examined by Northern Blot technique. Result Positive expression rates of UPA mRNA in GCT, NT and FATT were 85%, 31% and 10% respectively. UPA mRNA expression was not found in the early stage of the cancer, while it was much higher in advanced cancer. Gastric cancer with serosal invasion and lymph node metastasis had much higher expression rate. Conclusions UPA mRNA expression may be a indicator for evaluating the invasion and metastasis of gastric cancer.
出处
《中国普通外科杂志》
CAS
CSCD
2000年第4期315-317,共3页
China Journal of General Surgery
