摘要
目的探讨中孕期超声测量胎儿颈部皮肤皱褶（nuehalfold，NF）厚度的临床意义。方法对1984例中孕期（孕18～24周）产前超声筛查孕妇测量NF厚度，NF厚度≥6．0mm为NF增厚组，NF厚度〈6．0mm为对照组，观察NF增厚与胎儿染色体和胎儿结构异常的关系。结果1984例胎儿共发现NF增厚41例（NF增厚组），余1943例NF正常（对照组）。NF增厚组41例胎儿中26例检出胎儿结构异常（63．41％），9例有胎儿染色体异常（21．95％）。对照组1943例检出胎儿结构异常20例（1．03％），306例有产前诊断指征者羊膜腔或脐带穿刺检查发现胎儿染色体异常4例（1．31％，4／306）。NF增厚组胎儿结构异常率明显高于对照组（P〈0．01），胎儿染色体异常检出率明显高于对照组中有产前诊断指征者（P〈0．05）。结论胎儿NF增厚是中孕期超声筛查胎儿染色体异常的重要超声指标，胎儿NF增厚容易合并其他结构异常。
Objective To explore the clinical significance of fetal nuchal fold（NF） thickness in the second trimes- ter of pregnancy measured by ultrasound. Methods NF thickness was measured for prenatal ultrasound screening in 1 984 pregnant women in the second trimester of pregnancy （pregnancy at 18 -24 weeks）. NF thickness≥6 mm was as- signed to NF thickened group, NF thickness 〈 6 mm was assigned to control group. The relationships between NF thick- ening and fetal chromosomal abnormalities as well as structural fetal anomalies were observed. Results Thickened NF was found in 41 cases among 1 984 fetuses （NF thickened group） , while the remaining 1 943 cases had normal NF thick- ness（ control group）. Structural fetal anomalies were detected in 26 cases in NF thickened group （63.41%）, and fetal chromosomal abnormalities were found in 9 cases （21.95%）. 20 cases of structural fetal anomalies were detected in con- trol group of 1 943 fetuses （ 1.03% ） , 306 eases were punctured through amniotie sac puncture or umbilical cord punc- ture conforming to prenatal diagnosis indications, and 4 cases were revealed of fetus chromosomal abnormalities （1.31% , 4/306）. The rate of structural fetal anomalies in NF thickened group was significantly higher than that of control group （ P 〈 0. 01 ）. The detection rate of fetal chromosomal abnormalities in NF thickened group was obviously higher than those who had prenatal diagnosis indications in control group （ P 〈 0.05 ）. Conclusion Fetal NF thickening is an important ultrasound indicator in the second trimester of pregnancy screening for chromosomal abnormalities. Fetal NF thickening is often accompanied by other structural fetal anomalies.
出处
《徐州医学院学报》
CAS
2012年第12期821-823,共3页
Acta Academiae Medicinae Xuzhou
关键词
颈部皮肤皱褶
胎儿
超声
染色体异常
结构异常
nuchal fold
fetus
ultrasound
chromosomal abnormalities
structural anomalies
