摘要
目的 :评价腹腔内热灌注化疗对侵及浆膜的进展癌根治术后预防腹腔复发的疗效。方法 :1994年 12月～ 1996年 12月 96例可切除的进展期胃癌患者随机分成治疗组和对照组。治疗组 52例应用DDP 80mg +MMC 10mg +5 FU 1.0加入生理盐水 ( 0 .9% ) 150 0ml加热至 4 3℃ ,进行腹腔灌注 ,连用 4～ 6周。对照组 4 4例常规给予口服优福定。结果 :治疗组和对照组 3年生存率分别为 61.5%、4 5.5%(P <0 .0 1) ,腹腔复发率分别为 5.2 %、30 % (P <0 .0 1)。结论 :腹腔热灌注化疗可以预防侵犯浆膜的进展期胃癌术后腹腔复发 ,是一种安全。
Objective:To evaluate the effect of preventing the recurrence of peritoneal cavity with hyperthemic peritoneal prerfusion after resection of gastic canecer which had penetrated the serosa and visceral peritoneum.Methods:From December 1994 to December 1996.96 cases were devised into treatment group(groip 1)and control group (group2).52 cases(group1) were treated with hyrerthemic peritoneal prerfusion after resection of adrvace gastic cancer.DDP 80 mg and 5 FU 1.0 and MMe 10 mg in 1500 ml 0.9% sodinm chloride the thermometer 43℃were intrdperictoneally in jected erery week for 4 to 6 times,44cases(groupⅡ)as control were used to take tablets of UFT.Results:The 3-year survival rate in group Ⅰand gronp Ⅱwere 61 5%,45 5%( P <0 01) The recurrence of peritoneal cavity in group Ⅰand gronp Ⅱwere 5 2%,30%( P <0 01).Conclusions:This is a safe and effective methad for preoenting the recurrence of peritoneal cavity after resection of invading serosa from advanced gastric cancer.
出处
《肿瘤防治杂志》
2000年第3期261-262,共2页
China Journal of Cancer Prevention and Treatment
关键词
腹腔内热灌注化疗
胃肿瘤
预防
hyrerthemic preitoneal perfusion
stomach neoplasms
