摘要
目的:了解医院感染病原菌的流行病学特征及其耐药特点,为临床合理选择抗菌药物提供参考。方法:对本院2010年7月～2011年12月医院感染患者的各类送检标本中分离的病原菌种类、分布以及主要病原菌的耐药性进行回顾性分析。结果:医院感染病原菌主要来自痰液(占60.93%),其次是分泌物(占19.02%)、尿液(占7.46%);分离菌株以G-菌为主,占60.67%,其次为G+菌、真菌,分别占26.22%、13.11%。药敏结果显示,大肠埃希氏菌中产ESBLs菌株的检出率为47.06%,肺炎克雷伯氏菌中产ESBLs菌株的检出率为29.79%,耐碳青酶烯类抗菌药物的鲍曼不动杆菌检出率为32.61%,多药耐药的铜绿假单胞菌检出率为18.87%;金黄色葡萄球菌中MRSA的检出率为51.74%,凝固酶阴性葡萄球菌中MRCNS的检出率为23.53%,真菌对抗菌药物的耐药率低。结论:医院感染病原菌的分布范围较广、主要病原菌的耐药性较强,应引起临床高度重视。
Obiective： To study the epidemiological characteristics and drug resistance of pathogens causing nosocmial infections and guide rational information to choose antibiotics reasonably.Methods： The category,distribution and drug resistance of the major pathogens from patients of nosocmial infection from July 2010 to December 2011 were retrospectively analyzed.Results： The pathogens of nosocmial infection from the sputum（60.93%）,followed by discharge（19.02%）,urine（7.46%）.The main pathogens were the Gram-negative bacilli（60.67%）,followed by the Gram-positive cocci（26. 22%）,the fungi（13.11%）.Susceptibility results of drug shew that the detection rate of ESBLs in E.coli was 47.06%, and that in K.pneumoniae was 29.79%,the resistance rate of A.baumannii to carbopenems was 32.61%,the detection rate of multidrug-resistant pseudomonas aeruginosa was 18.87%.the rate of MRSA in S.aureus was 51.74%,the rate of MRCNS in plasma-coagulase negative staphylococcus was 23.53%,the resistance rate of fungi to antimicrobial drugs was low.Conclusion： The pathogen causing nosocomial infections from a wide variety of sources and the drug resistance of the main pathogen was very high,It is very important to pay high clinical attention to those strains for the clinical treatments.
出处
《赣南医学院学报》
2012年第6期893-896,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
医院感染
病原菌
耐药性
Nosocomial infection
Pathogen
Drug resistance
