摘要
目的探讨血清胸苷激酶1(TK1)、特异性组织多肽抗原(TPS)、糖类抗原15-3(CA15-3)联合检测在乳腺癌诊断中的临床价值。方法采用免疫印迹-增强化学发光法对乳腺癌组(69例)、乳腺良性疾病组(52例)、健康对照组(48例)血清TK1进行检测,采用酶联免疫吸附试验(ELISA)对血清TPS进行检测,采用化学发光法对血清CA15-3进行检测,并对检验结果进行统计学分析。结果乳腺癌患者血清TK1、TPS、CA15-3水平均显著高于乳腺良性疾病组与健康对照组(P<0.01),3项指标联合检测的敏感性显著高于单项检测或2项联合检测(P<0.05)。结论检测血清TK1、TPS、CA15-3水平,对乳腺癌的诊断具有重要的价值,3种标志物联合检测能明显提高乳腺癌诊断的敏感性。
Objective To investigate the clinical value of combined detection of serum thymidine kinase 1 （ TK1 ）, tissue polypeptide specific antigen （ TPS ） and carbohydrate antigen 15-3 （ CA15-3 ） in diagnosis of breast cancer.Methods The levels of serum TK1were detected by enhanced chemiluminiscence dot-blot assay in 69patients with breast cancer , 52patients with benign breast disease and 48healthy controls.The levels of serum TPS were detected by enzyme-linked immunosorbent assay （ ELISA ） .The levels of serum CA15-3were detected by chemiluminescence immunoassay.The test results were statistically analyzed.Results The levels of TK1 , TPS and CA15-3in patients with breast cancer were significantly higher than those in patients with benign breast disease and healthy controls （ P0.01 ） .The sensitivity of combined detection of three markers was significantly higher than that of single or double-combined detection （ P0.05 ） .Conclusion Serum TK1 , TPS and CA153 might have important value in diagnosis of breast cancer.Combined detection could significantly improve the diagnostic sensitivity of breast cancer.
出处
《国际检验医学杂志》
CAS
2012年第16期1943-1944,1946,共3页
International Journal of Laboratory Medicine
关键词
乳腺肿瘤
胸苷激酶1
特异性组织多肽抗原
糖类抗原15-3
breast neoplasms
thymidine kinase 1
tissue polypeptide specific antigen
carbohydrate antigen 15-3
