摘要
目的研究中晚期肺腺癌患者体内癌胚抗原(CEA)、神经特异性烯醇化酶(NSE)、细胞角蛋白21-1片段(CYFRA21-1)、糖类抗原125(CA125)的水平变化,为临床提供诊断依据。方法选择该院2009年10月至2011年5月住院接受治疗的中晚期肺腺癌患者65例作为研究对象,按照肺癌分期标准Ⅱ期患者15例,Ⅲ期患者39例,Ⅳ期患者11例。对所有中晚期肺腺癌患者体内肿瘤标记物包括CEA、NSE、CYFRA21-1及CA125进行检测,检测方法采用电化学分析法,并分析其血清标记物水平同患者疾病严重程度的相关性。结果结果显示不同癌症分期患者体内相应的肿瘤标记物水平有所不同,Spearman相关性分析显示其水平高低同患者分期具有显著相关性,随患者分期的加重,肿瘤标记物水平整体升高,P<0.05。结论肺腺癌患者体内肿瘤标记物水平同患者分期具有显著正相关性,针对肺腺癌患者检查肿瘤标记物可以有助于鉴别肺癌的分期,可以作为肺癌诊断的辅助指标。
Objective To study the changes of levels of CEA , NSE , CYFRA21-1 , CA125in patients with lung adenocarcinoma and provide the evaluatio of diagnosising.Methods 65cases of lung adenocarcinoma palients were selected in the hospital from Oct 2009to May 2011 , which were divided into different kinds due to the lung cancer staging standard with the second stage 15cases , 29in third stage , 11in fourth stage.All the observations were tested by electrochemical analysis , and analysis the correlation of the seriousity with cancer.Results It was obviously different that patients in different stages got different dumor markers.Moreover by using Spearman correlation analysis , show very clear correlation between stages of cancer and the levels of tumor markers , they had apositive correlation （ P0.05 ） .Conclusion There is notable correlation between the stages of cancer and the levels of tumor markers , by using tumor markers could have the better way to tell the stages of lung cancer , which could provide good opportunities for the treat afterwards.
出处
《国际检验医学杂志》
CAS
2012年第16期1939-1940,共2页
International Journal of Laboratory Medicine
关键词
肺肿瘤
肿瘤分期
癌胚抗原
神经特异性烯醇化酶
糖类抗原125
lung neoplasms
neoplasm staging
carcinoembryonic antigen
neuro-specific enolase
carbohydrate antigen 125
