摘要
目的 观察中药复方制剂活血通脉片 ( HXTMT)对实验性心肌缺血状态下犬和缺血性心脏病患者的血液流变学的影响 .方法 1用犬作为实验材料 ,结扎其冠状动脉 ,造成急性心肌缺血 (“血瘀证”)模型 ,经十二指肠灌入实验药物 ,从犬心大静脉留取血样 ,检测实验性心肌缺血的血液流变学重要指标 ;2选择符合 WHO制定的缺血性心脏病的命名及诊断标准患者 ,口服 HXTMT4片 ,3次 .d- 1 ,1mo为 1疗程 ,采用自身对照 ,检测治疗前后冠心病心绞痛患者的血液流变学指标 .结果 该中药制剂能降低实验性心肌缺血犬及冠心病心绞痛患者的全血高切、低切、血浆粘度和加快红细胞电泳时间 ,与对照组比较有显著差异 ( P<0 .0 5 ,P<0 .0 1) .
AIM To study the effect of Huoxue tongmai tablet (HXTMT) on hemorrheology of experimental canineand patients with myocardial ischemia. METHODS ① The coronary artery ligation was employed to establish a myocardial ischemia model with canine as subject (Blood Stasis). Coronary sinus cannula was inserted through the exteral jugular vein and HXTMT was duodenally perfused; hemorrheological indexes was measured before and after ligation; ② Patients with myocardial ischemia were given HXTMT 4 tablets, 3 per day for 1 mo, and hemorrheogical indexes were measured before and after therapy. RESULTS In comparison with control, hemorrheological indexes such as whole blood high and lowshear viscosity, plasma viscosity, and erthrocyte electrophoretic time (EET) reduced significantly in myocardial ischemia canine and patients (P< 0.05 , P< 0.01 ). CONCLUSION HXTMT could improve hemodynamics of blood hyperviscosity sydrome in experimental canine and patients with myocardial ischemia.
出处
《第四军医大学学报》
2000年第5期S081-S083,共3页
Journal of the Fourth Military Medical University
基金
军队新药研究重点项目![118(1998)]
关键词
活血通脉片
心肌缺血
血流流变学
药效学
Huoxue Tongmai tablet
myocardial ischemia
hemorrheology
canine
