摘要
阐明宿主和病毒间的相互作用对于理解病毒的复制、致病性和毒力至关重要,本文对小RNA病毒感染和复制过程中参与的宿主蛋白和病毒蛋白的功能最新研究进展做一综述。首先讨论病毒衣壳蛋白和宿主细胞受体间的相互作用,然后详述病毒复制过程中参与的病毒蛋白和宿主细胞蛋白。
Understanding of the interaction between the host and the virus is essential to viral replication, pathogenicity and virulence. The article gives an overview of progress on the functions of host and viral proteins that are participated in picor- navirus infection and replication. Firstly the interactions of viral capsid proteins with host cell receptors had been discussed, and then the viral and host cell proteins that are participated in picornavirus replication had been elucidated. To illuminate how cellular proteins interact with viral proteins or viral RNA will provide insights for the design of novel antiviral agents based on these interactions.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2013年第1期82-85,90,共5页
Chinese Journal of Zoonoses
基金
国家自然科学基金(31100688,31101838)
甘肃省科技重大专项(1102NKDA033,1102NKDA034)
甘肃省国际科技合作计划项目(1104WCGA185)~~
