摘要
目的观察人脐带间充质干细胞静脉输注治疗慢性肝功能衰竭患者的近期疗效。方法 18例肝硬化合并慢性肝衰竭患者分为两组,治疗组9例在内科综合治疗基础上通过外周静脉输注脐血干细胞,每次干细胞回输量为(12～62)×109/L,每周一次,连续输注1～3次为1个疗程。对照组9例仅给予常规内科综合治疗。分别观察间充质干细胞治疗前及治疗后4周患者临床症状、血液生化、血凝等指标变化。结果经人脐带间充质干细胞治疗后4周,白蛋白和凝血酶原活动度较治疗前明显升高,差异有统计学意义(P<0.05)。症状和体征改善两组无显著差异。结论通过外周静脉输注人脐带间充质干细胞治疗慢性肝衰竭患者,在近期内可明显改善肝功能衰竭患者症状,提升白蛋白等肝脏指标。
To investigate short-time clinical effects of human umbilical cord-derived mesenchymal stem cells （UCMSCs） transplantation in treatment of patients with chronic liver failure. Methods 18 patients with decompensated cirrhosis and chronic liver failure were involved and divided into 2 groups. 9 patients in the control group were treated with conventional therapy, while 9 patients in the transplantation group were treated with UCMSCs transplantation via peripherally venous based on conventional therapy. Results After transplantation, albumin level in the transplanta- tion group showed an ascend trend and had a significant increase （P 〈 0.05） compared with the control group after 4 weeks of transplantation. Meanwhile, both alanine aminotransferase and prothrombin time levels began to decrease at 2 weeks after transplantation and were significantly lower than those of the control group （ P 〈 O. 05 ） after 4 weeks of transplantation. The differences in clinical symptoms and signs between the 2 groups were not significant （P 〉 0.05 ）. Conclusion The transplantation of UC-MSCs via peripherally venous is effective in short time for treatment of patients with chronic liver failure.
出处
《胃肠病学和肝病学杂志》
CAS
2013年第1期22-24,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
脐带间充质干细胞
慢性肝衰竭
肝硬化
Human umbilical cord-derived mesenchymal stem cells
Chronic liver failure
Cirrhosis
