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吡格列酮对2型糖尿病患者血清脂联素水平的影响 被引量:4

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摘要 目的探讨吡格列酮对2型糖尿病患者血清脂联素水平及胰岛素抵抗的影响。方法将符合2型糖尿病诊断标准的60例患者随机分为治疗组和对照组各30例,均给予常规治疗,治疗组在常规治疗的基础上给予吡格列酮片。2组疗程均为12周,治疗前后分别检测空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血脂(TG、TC、LDL-C、HDL-C)、空腹胰岛素(FINS)及脂联素(APN),计算胰岛素抵抗(IR)水平。结果治疗组治疗后FBG、HbA1c、TC、TG、LDL-C等指标均明显降低,IR明显改善,血浆APN水平显著升高,与对照组比较均有显著性差异(P均<0.05)。结论吡格列酮除改善血糖及IR外,还可使血浆APN水平升高。
机构地区 天津市南开医院
出处 《现代中西医结合杂志》 CAS 2013年第4期390-391,共2页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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  • 1Combs TP,Wagner JA,Berger J. Induction of adipocyte comp-lement-related protein of 30 kilodaltons by PPARgamma agonists:a potential mechanism of insulin sensitization[J].Endocrinology,2002.998-1007.
  • 2Haffner SM,Gonzalez C,Miettinen H. A prospective analysis of the Homa model.The Mexicocity diabetes study[J].Diabetes Care,1996.1138-1141.
  • 3Yang WS,Lee WJ,Funahash i T. Weigh336t reduction increase plasma levels of an adipose-derived anti-inflammatory protein,adiponectin[J].ClinEndocrinol Metab,2001,(08):3815-3819.
  • 4Ouchi N,Kihara S,Arita Y. Adiponectin,an adipocy tederived plasm a protein,inhibits endothelial NF-kappa β sinaling through a cAMP-dependent pathway[J].Circulation,2000,(11):1296-1301.
  • 5Ouchi N,Kihara S,Arita Y. Novel modulator for endothelial adhesion molecules:adipocyte-derived adiponectin[J].Circulation,1999,(05):2473-2476.
  • 6Hotta K,Funahashi T,Bodkin NL. Circulating concent rations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensit-ivity during the progression to type 2 diabetes in rhesus monkeys[J].Diabetes,2001,(05):1126-1133.
  • 7Yamauchi T,Kamon J,Minokoshi Y. Adiponectin stimulates glucose utilization and falty-acid oxidation by activating AMP-actived protein Kinase[J].Nature Medicine,2002,(11):1288-1295.
  • 8Combs TP,Wagner JA,Berger J. Induction of adipocyte complement related protein of 30 kilodaltons by PPARgamma agonists:apotential mechanism of insulin sensitization[J].Endocrinology,2002,(03):998-1007.

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