摘要
目的探讨腹腔镜手术联合米非司酮治疗对子宫内膜异位症患者血清金属蛋白酶-9(MMP-9)/组织抑制因子-1(TIMP-1)平衡的影响。方法将100例子宫内膜异位症患者随机分为两组,对照组50例,治疗组50例;对照组采用腹腔镜手术联合孕三烯酮治疗,治疗组采用腹腔镜手术联合米非司酮治疗。治疗3个月后评价总疗效,酶联免疫吸附试验(ELISA)法检测患者治疗前和治疗后3个月血清MMP-9和TIMP-1。结果在治疗后3月,治疗组总疗效92%,对照组总疗效84%,治疗组明显优于对照组(P<0.05)。治疗后两组的MMP-9/TIMP-1均有下降,但与对照组相比,治疗组比治疗前下降程度更明显(P<0.05)。结论腹腔镜手术联合米非司酮治疗子宫内膜异位症可以通过改善MMP-9/TIMP-1平衡而改善子宫内膜异位症患者病情。
Objective To study the effectiveness of laparoscopic surgery combined with mifepristone on the levels of matrix metalloproteinase-9 （MMP-9）/matrix tissue inhibitor of metalloproteinase-1 （ TIMP-1 ） in patients with endometriosis. Methods One hundred patients with endometriosis were randomly divided into two groups, the control group （ n = 50 cases） and the treat- ment group（ n =50 cases）. The patients in the control group were treated through laparoscopic surgery and gestrinone;while the patients in the treatment group were treated through laparoscopic surgery plus mifepristone. The MMP-9 and TIMP-1 were detec-ted. Results The total effective rates were 92% of the treatment group and 84% of the control group. There was a significantly difference （P 〈 0.05 ）. There had a drop of MMP-9/TIMP-1 in two groups, but a significantly difference in the treatment group be-fore and after treatment （ P 〈0. 05 ）. Conclusion Laparoseopic surgery plus mifepristone could improve the balance of MMP-9/ TIMP-1, through which treating endometriosis.
出处
《中华全科医学》
2013年第2期214-215,219,共3页
Chinese Journal of General Practice
关键词
腹腔镜
米非司酮
子宫内膜异位症
金属蛋白酶-9
组织抑制物-1
Laparoscopic surgery
Mifepristone
endometriosis
matrix metalloproteinase-9
Tissue inhibitor of metalloprotein-ase-1
