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抑癌基因PTEN与皮肤疾病

PTEN and skin disease
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摘要 第10号染色体同源丢失性磷酸酶张力蛋白基因（Phosphatase and tension homologue deleted onchromosome ten,PTEN）作为一个肿瘤抑制基因，其编码的蛋白具有双重磷酸酶活性，在细胞的生长、凋亡、分化、粘附、迁移等许多生理、病理过程中发挥重要调控作用。研究表明，PTEN基因不仅参与细胞周期调控，而且调控细胞的正常生长与发育，具有广泛的生物学功能。目前，发现PTEN在皮肤疾病中也有重要的作用和意义，本文就近年来PTEN在皮肤疾病中的作用和意义做一综述。
作者 郭亮 桂思 徐凯
机构地区 武汉总医院皮肤整形科
出处 《中国美容医学》 CAS 2013年第1期214-216,共3页 Chinese Journal of Aesthetic Medicine
关键词 抑癌基因PTEN 第10号染色体同源丢失性磷酸酶张力蛋白基因 皮肤疾病 细胞周期调控 肿瘤抑制基因 PTEN基因 调控作用 磷酸酶活性
分类号 R737.9 [医药卫生—肿瘤]
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参考文献27

  • 1Di Cristofano A, Pesce B, Cordon-Cardo C. et al Pten is essential for embryonic development and tumour suppression [J]. Nat Genet, 1998,19(4):348-355.
  • 2Feilotter HE,Nagai MA,Boag AH,et al. Analysis of PTEN and the 10q23 region in primary prostate carcinomas [J].Oncogene,1998,16 (13):1743-1748.
  • 3Marsh DJ,Roth S,Ltmetta KL,et al.Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome[J]. Cancer Res, 1997,57(22):5017-5021.
  • 4Georgescu MM,Kirsch KH,Kaloudis P,et al.Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor[J]. Cancer Res,2000,60(24):7033-7038.
  • 5Adey NB,Huang L,Ormonde PA,et al.Threonine phosphorylation of the MMAC 1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding[J].Cancer Res,2000,60( 1 ):35 -37.
  • 6Valiente M,Andres-Pons A,Gomar B,et al. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases [J].J Biol Chem, 2005,280(32): 28936-28943.
  • 7Ikenoue T,Inoki K,Zhao B,et al.PTEN acetylation modulates its interaction with PDZ domain [J].Cancer Res, 2008,68 (17): 6908-6912.
  • 8Palmitessa A,Benovic JL.Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity[J].J Biol Chem,2010,285(20): 15187-15200.
  • 9Li DM,Stm H.PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells[J].Proc Natl Acad Sci USA,1998,95(26): 15406-15411.
  • 10Fumari FB,Huang HJ,Cavenee WK.The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive GI growth arrest in glioma cells[J].Cancer Res,1998,58(22):5002-5008.

二级参考文献13

  • 1郁成雨,潘真,王春刚,闵锐,姚雨石,赵芳,韩玲.RNA干扰抑制RAD51基因表达对放射敏感性影响的实验研究[J].中华肿瘤防治杂志,2006,13(24):1852-1855. 被引量：3
  • 2Ambrosini G, Adida C, Altieri D C. A novel anti-apoptosis gene, Survivin, expressed in cancer and lymphoma[J]. Nat Med,1997,3(8):917-921.
  • 3Li F, Ambrosini G,Chu E Y. Control of apoptosis and mitotic spindle checkpoint by Survivin[J]. Nature, 1998, 396 (6711) : 580-584.
  • 4O~Connor D S, Schechner J S, Adida C, et al. Control of apoptosis during angiogenesis by Survivin expression in endothelial cells[J]. Am J Pathol, 2000,156(2) :393-398.
  • 5Arnab C, Gary G Z, Min Z, et al, Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms[J]. Oncogene, 2004,23(45) : 7494-7506.
  • 6Masashi N, Naoki T, Koichi A, et al. Survivin as a predictor of cis diamminedichloroplatinum sensitivity in gastric cancer patients[J]. Cancer Sci, 2004,95(1):44-51.
  • 7Shin S, Sung B J, Cho Y S. An anti apoptotic protein human Surviving is a direct inhibitor of caspase-3 and -7[J]. Biochemistry, 2001,40(4) :1117-1123.
  • 8O'Connor D S, Wall N R, Porter A C, et al. A p34(cdc2) survival checkpoint in cancer[J]. Cancer Cell,2002,2(1):43-54.
  • 9Suzuki A, Hayashida M, Ito T. Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16 (INK4a) and Cdk2/cyelin E complex activation[J]. Oncogene, 2000,19 (29): 3225-3234.
  • 10Suzuki A, Ito T, Kawano H. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fasmediated cell death[J]. Oncogene, 2000,19(10) :1346-1353.

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中国美容医学
2013年 第1期

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