摘要
目的 :探讨心力衰竭患者可溶性肿瘤坏死因子受体I(STNF RI)血清水平的变化及ACEI对STNF RI的影响。方法 :采用双抗体夹心ELISA法 ,测定了CHF患者 62例和正常对照组 30例的血清STNF RI水平。并观察心功能Ⅲ级以上CHF患者用苯那普利治疗 1个月后的STNF RI血清水平。结果 :STNF RI在心功能Ⅱ、Ⅲ、Ⅳ级患者 ,均较正常对照组明显升高 (P <0 0 1) ;而且随着心功能的恶化 ,血清STNF RI水平逐渐升高 ,各级CHF患者之间均有显著性差异 (P <0 .0 1) ;苯那普利治疗组STNF RI水平明显下降 (P <0 0 5)。结论 :CHF患者血清STNF RI水平升高 ,尤其是心功能Ⅲ、Ⅳ级的患者更为明显 ;STNF RI可以作为病情严重程度的判断指标 ;苯那普利可降低CHF患者血清STNF
Objective:To study the change of serum soluble necrosis factor receptor I (STNFR Ⅰ) and effect of angiotention converting enzyme inhibitor(ACEI) on STNFR Ⅰ in patients with congestive heart failure(CHF)Method:Serum STNFR Ⅰ in 62 CHF patients and 30 normal subjects were measured with enzymelinked immunosorbent assayAfter one month’s treatment with Benazepril,serum STNFR Ⅰ was measured again in patients whose cardiac function was of classⅢ and class ⅣResults:(1)Serum level of STNFR I was significantly higher in CHF patients than in healthy subjects(P<001);(2)After one month’s treatment,the serum STNFR Ⅰ decreased significantly in Benazepril group(P<001).Conclusion:The results showed that serum level of STNFR Ⅰ could be used as an index of illness severity and Benazepril could decrease the serum level of STNFR Ⅰ
出处
《山东医科大学学报》
2000年第2期166-167,170,共3页
Acta Academiae Medicinae Shandong
关键词
充血性心力衰竭
STNF-RI
ELISA
苯那普利
Receptors,tumor necrosis factor
Heart failure,congestive
Enzyme-linked immunosorbent assay
Benazepril
