摘要
目的探讨肝动脉化疗栓塞(TACE)联合微波消融(MWA)治疗大肝癌的疗效及预后影响因素。方法对32例大肝癌患者行TACE联合MWA治疗。结果 32例患者中CR 9.4%(3/32),PR 56.3%(18/32),SD 25.0%(8/32),PD 9.4%(3/32),中位生存时间为(19.0±2.7)个月,1、2年生存率分别为66.1%和36.9%。单因素及Cox回归分析显示,肿瘤大小、Child分级、病灶数目、是否伴有门静脉血栓均是影响患者预后的独立因素。结论 TACE联合MWA治疗大肝癌是1种安全有效的治疗方式,值得临床推广应用。
Objective To evaluate the effects and prognostic factors of transcatheter chemoembolization（TACE） combined with microwave ablation（MWA） in treating patients with large hepatocellular carcinoma.Methods 32 patients with large hepatocellular carcinoma were treated with TACE followed by MWA.Results Of the 32 patients,3 patients（9.4%） achieved complete remission,18 patients（56.3%） achieved partial remission,8 patients（25.0%） achieved stable disease,and 3 patients（9.4%） achieved progressive disease.The median survival time of 32 patients was（19.0±2.7）months,and the 1 and 2-year survival rates were 66.1% and 36.9%.Univariate and Cox regression analysis indicated that tumor size,Child grade,number of lesions,and portal thrombosis were independent prognostic factors of survial.Conclusion The combination of TACE and MWA is a promising approach for patients with large hepatocellular carcinoma.
出处
《实用癌症杂志》
2013年第1期64-67,共4页
The Practical Journal of Cancer
关键词
肝癌
化疗栓塞
微波消融
联合治疗
Hepatocellular carcinoma
Chemoembolization
Microwave ablation
Combination therapy
