摘要
目的探讨姜酚对牛II型胶原诱导性关节炎(Collagen Induced Arthritis,CIA)大鼠的抗炎作用及其机制。方法将6周龄雌性Wistar大鼠随机分为空白对照组、模型组、姜酚组和雷公藤多苷组,每组10只。制备CIA模型,观察姜酚对CIA大鼠关节病理、关节炎指数的变化及对大鼠血清肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)、白介素-1β(IL-1β)表达的影响。结果姜酚能够抑制CIA大鼠踝关节肿胀,降低关节炎指数,并能降低血清TNF-α、IL-1及IL-1β水平,减轻关节滑膜细胞增生、滑膜层及滑膜下层淋巴细胞浸润,其疗效与雷公藤多苷组相当(P>0.05)。结论姜酚对CIA大鼠关节炎具有治疗作用,其机制可能与下调TNF-α、IL-1和IL-1β有关。
Objective To study the anti-inflammatory effect and mechanism of gingerol on collagen-induced arthritis in rats. Methods Forty 6-week-aged females Wistar rats were randomly divided into 4 groups, blank group, model group, gingerol treatment group and tripterygium glycosides control group. Rat CIA model was established for the ob- servation of the effect of gingerol on CIA rat ankle pathology, arthritis index and serum tumor necrosis factor alpha （TNF-α）,interkeukin I（IL-1 ）, and IL-1β levels in rats. Results Gingerol could inhibit the swelling of ankle joint of CIA rats, reduce arthritis index, and decrease the serum levels of TNF-α, IL-1 and IL-1β, and significantly relieve the synovial cells proliferation and lymphocyte infiltration in synovial layer and synovial underlayer, which was similar to tripterygium glycosides（P 〉 0.05）. Conclusion Gingerol has remarkable curative effect on CIA in rats, and the therapeutic mechanism may be related with the down-regulation of serum inflammation factors levels of TNF-α, IL-1 and IL-1β in CIA rats.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2013年第1期47-51,共5页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
贵州省中医药管理局项目(QZYY2011-20)
贵州省中医药民族医药重点学科项目(2011年)
