摘要
药物引起的肝毒性是老年人肝脏疾病的重要原因,发生率是年轻人的4倍多,且类型几乎包括了所有已知的肝脏疾病。因为大多数的临床试验排除了大于75～80岁年龄组患者,有关药物副作用的报告在大于60岁年龄组中相当罕见。为此,需要进一步的临床研究,以探讨老年患者肝脏的药物副作用。本文主要综述了老年药物性肝损害的主要临床表现和诊断以及近年来常见药物(心血管药物和抗微生物药物)引起肝损伤的临床情况。
Drug-induced hepato-toxicity was an important reason for the liver disease in elderly,which was four times more common than in adults and might include all known liver disorders. Reports related to drug side effects were rare in people 〉 60 years of age group since most clinical trials exclude patients 〉 75 - 80 years of age. Further clinical studies should be need to investigate he- patic side effects of drugs in elderly patients. The main clinical manifestations and diagnosis of drug-induced liver injury in elderly as well as common drugs （cardiovascular drugs and anti-microbial agents） cause liver injury in clinical conditions were reviewed in this paper.
出处
《药学实践杂志》
CAS
2013年第1期22-23,66,共3页
Journal of Pharmaceutical Practice
关键词
老年人
不良反应
药物性肝损害
elderly
adverse event
drug-induced liver injury
