摘要
目的探讨儿童过敏性鼻炎患者血清血管细胞间黏附分子-1(VCAM-1)、白细胞介素-4(IL-4)、白细胞介素-12(IL-12)表达水平和作用,以及丙酸氟替卡松鼻喷雾剂的干预作用。方法采用ELISA法检测32例变应性鼻炎患者应用丙酸氟替卡松鼻喷雾剂治疗前、治疗1个月后以及20例健康体检者外周血清VCAM-1、IL-4、IL-12水平。结果过敏性鼻炎患者治疗前血清中sVCAM-1、IL-4、IL-12的含量与健康体检组比较,差异有统计学意义(P<0.05)。过敏性鼻炎患者血清中sVCAM-1、IL-4、IL-12的含量经使用丙酸氟替卡松鼻喷雾剂治疗前后比较,差异有统计学意义(P<0.05)。过敏性鼻炎患者治疗后血清中sVCAM-1、IL-4、IL-12的含量与正常对照组比较,差异无统计学意义(P>0.05)。结论 VCAM-1、IL-4、IL-12在过敏性鼻炎的发生发展中起着重要的作用。丙酸氟替卡松鼻喷雾剂鼻腔局部用药可以通过抑制VCAM-1和调节Th1/Th2型细胞因子的动态平衡来治疗过敏性鼻炎。
Objective To investigate the expression level of serum vascular cell adhesion molecule - 1 （ sVCAM - 1 ） ,interleukin - 4 （IL- 4）andinterleukin -12（ IL- 12） ,and study the role of fluticasone propionatein in childhood patients with allergic rhinitis. Methods The expression level of VCAM - 1 ,IL -4,IL - 12 in 32 patients with allergic rhinitis and 20 normal men were detected by ELISA before the treatment,and 1 month after treatment. Results The expression level of VCAM - 1, IL - 4,1L - 12 in patients with allergic rhinitis, was significantly different between the patient group and the control group. The expression level of VCAM -l ,IL -4 ,IL -12 was significantly different in patients with allergic rhinitis before the treatment and post - treatment. The expression level of VCAM - 1, IL -4, IL - 12 in post - treatment patients was not significantly different to that in the control group. Conclusion VCAM - l ,IL - 4 and IL - 12 may play an important role in development of allergic rhinitis. VCAM - 1 and Thl/Th2 Cell factors can be down - regulated by fluticasone propionate.
出处
《医学研究杂志》
2013年第1期40-43,共4页
Journal of Medical Research
