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乳腺癌脑转移的表观遗传学研究进展 被引量:1

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摘要 乳腺癌是我国乃至全球范围内女性最常见的恶性肿瘤,发病率呈逐年增高和年轻化趋势。虽然总体治疗方法较多,但仍有约50%的患者在首次治疗后的5年内出现复发转移,包括脑转移在内的远处转移是乳腺癌致死的主要原因。在脑转移的治疗中,传统手术的价值有限,虽然根治剂量的放疗可以达到治疗目的,但是由此产生的对脑组织的高损伤及致残性,极大程度限制了该手段的应用。相对而言,内科治疗(包括化疗、内分泌治疗和生物靶向治疗)是预防和治疗脑转移的重要手段[1]。
出处 《医学研究杂志》 2013年第1期10-13,68,共5页 Journal of Medical Research
基金 国家自然科学基金资助项目(81072175 81102010) 上海市科委基金资助项目(06DZ19505 114119a7500) 上海市卫生局科研项目(2009113 2011198) 上海市重点学科建设项目(B905)
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同被引文献4

  • 1何静,冯奉仪,邢镨元,王兴元,张频.乳腺癌脑转移67例临床分析[J].癌症,2005,24(12):1527-1530. 被引量:5
  • 2钱宜珊,张勇进.脉络膜转移癌[J].国外医学(眼科学分册),2005,29(6):404-407. 被引量:10
  • 3李风鸣.中华眼科学[Mj.北京:人民卫生出版社,2005:2054-2056.
  • 4Demirei H, Shields CL, Chao AN, et aI.Uveal metastasis from breast cancer in264 patients [J]. Am J Ophthalmol,2003. 136 (2) :264-271.

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