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Livin抑制凋亡的作用机制及其与肿瘤治疗的关系的研究进展 被引量：7

Anti-apoptotic mechanism of Livin and its relations with cancer therapy:literature review of recent advances
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摘要 Livin是凋亡抑制蛋白(IAP)的新成员,在许多肿瘤组织中明显过表达。研究其结构与功能及其作用机制对于理解肿瘤的发生和发展、抗肿瘤药物筛选、治疗选择和预后判断的有重要意义。笔者就上述相关问题的研究进展进行综述。 Livin, a novel member of inhibitor of apoptosis proteins （IAP）, is overexpressed in a variety of tumor tissues. Investigation of its structure and function, and its mechanisms of action has important significance for understanding the occurrence and development of the tumors and anticancer drug screening as well as treatment planning and prognosis estimation for cancers. This paper overviews the recent progress in the above relevant issues.
作者 李辰生 王吉文
机构地区 山东大学附属省立医院胃肠外科 浙江大学医学院附属第二医院胃肠外科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2013年第1期104-108,共5页 China Journal of General Surgery
基金 山东省2010年度优秀中青年科学家科研奖励基金计划医药卫生资助项目(BS2010YY060)
关键词 LIVIN 肿瘤组织 抑制凋亡 治疗 凋亡抑制蛋白 药物筛选 预后判断 过表达 Livin Inhibitor of Apoptosis Proteins Neoplasms Review
分类号 R730.2 [医药卫生—肿瘤]
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参考文献14

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同被引文献52

  • 1邓良,袁华,喻宗沅.绿原酸的研究进展[J].化学与生物工程,2005,22(7):4-6. 被引量：106
  • 2邱实,谭升顺,张江安,刘安,袁景奕,饶国洲,王文勇.姜黄素诱导人黑色素瘤A375细胞凋亡以及对c-myc、caspase-3表达的影响[J].第一军医大学学报,2005,25(12):1517-1521. 被引量：15
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  • 4Ma QL, Zuo X, Ubeda OJ, et al. Curcumin suppresses soluble Tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human Tau transgenic mice [J]. J Biol Chem, 2013, 288 (6): 4056- 4065.
  • 5Jiang T, Zhi XL, Zhang YH, et al. Inhibitory effect of curcumin on the A1 (III) -induced A:142 aggregation and neurotoxicity in vitro [J]. Biochim Biophys Acta, 2012, 1822 (8): 1207- 1215.
  • 6Agrawal A, Timothy J, Pandit L, et al. Post-traumatic epilepsy: an overview [J]. Clin Neurol Neurosur, 2006, 108 (5): 433-439.
  • 7Mastroberardino PG, Hoffman EK, Horowitz MP, et al. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson : s disease [J]. Neurobiol Dis, 2009, 34 (3): 417-431.
  • 8Sharma V, Babu PP, Singh A, et al. Iron-induced experimental cortical seizures & electroencephalographic mapping of seizure spread in the subcortieal brain areas [J]. Seizure, 2007, 16 (8): 680- 690.
  • 9Ashhab Y, AlianA, PolliackA, et al. Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern [J]. FEBS Lett, 2001, 495 (122): 56-60.
  • 10Earley CJ, Connor JR, Beard JL, et al. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome [J]. Neurology, 2000, 54 (8): 1698-1700.

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中国普通外科杂志
2013年 第1期

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