摘要
目的探索化疗对晚期胃癌TAM、CEA、CA72-4的影响及临床意义。方法应用电化学免疫发光法对49例胃癌患者化疗前后血清中CEA、CA72-4进行检测;应用生化法对其血清TAM进行检测,并均与健康对照组进行比较。结果晚期胃癌患者化疗后血清中TAM、CEA、CA72-4分别为(99.00±17.00)u/ml、(24.17±7.54)ng/ml、(48.44±17.36)u/ml;健康对照组分别为(70.00±12.00)u/ml、(4.24±1.28)ng/ml、(5.49±1.89)u/ml,两组差异具有统计学意义(P<0.01);亚组分析显示化疗有效的病例(PR+SD)化疗前后TAM分别为(123.00±21.00)u/ml、(97.00±16.00)u/ml;CEA、CA72-4化疗前分别为(25.80±2.57)ng/ml、(47.69±13.19)u/ml,化疗后分别为(21.56±7.87)ng/ml、(38.47±14.23)u/ml,差异有统计学意义(P<0.01,P<0.05)。临床进展的病例(PD)化疗前TAM、CEA分别为(117.00±18.00)u/ml和(21.34±5.68)ng/ml,化疗后分别为(140.00±17.00)u/ml和(30.94±8.79)ng/ml,差异有统计学意义(P<0.01);CA72-4化疗前后分别为(41.78±11.99)u/ml和(50.34±17.06)u/ml,差异有统计学意义(P<0.05)。结论 TAM、CEA、CA72-4的联合检测可作为一种评价化疗效果的早期预测指标。
Objective To explore the effect of late gastric cancer chemotherapy on expression of TAM CEA,CA72-4 and clinical significance. Methods Application of the method of electrochemical immune shine gastric cancer patients in 49 cases before and after chemotherapy was used to detect plasma CEA and CA72 4;The biochemical method was used to test plasma TAM in patients compared with controls. Results In patients with advanced stomach cancer after chemotherapy,the plasma levels of TAM,CEA, CA72 4 were （99.00 ±17.1）01 u/ml, 124. 17 ± 7. 541 ng/ml, （ 48.44 ± 17.36 ） u/ml, respectively. And in control group,they were（70.00 ± 12.00 ）u/ml, （4.24 ± 1.28） ng/ml, （5.49 ± 1.89 ）u/ml respectively. There was significant difference（P^0.01 ）. Sub group analysis showed that chemotherapy effective cases （PR ＋ SD）, the TAM level before chemotherapy or after chemotherapy was（1.23.00 ±21.00） u/ml or 197.00± 16.001u/ml,respectively;CEA and CA72-4 were （25.80±2.57） ng/mI, （47. 69 ±13.19） u/ml or 121.56 ± 7.87） ng/ml, （38.47 ± 14. 231 u/ml, respectively. The difference was statistically significant （P〈0. 01 ,P〈0.05）. In clinical progress of cases （PD） ,the levels of TAM and CEA before chemothera- py or after chemotherapy were（117.00 ± 18.00）u/ml and（21.34± 5.68） ng/ml or were （140.00± 17.00 ）u/ml and （30. 94 ±8. 79）ng/ml, respectively. The difference had statistical significanee（P〈0. 01 ）; CA72-4 before or after chemotherapy was （41. 78 ± 11.99 ）u/ml or（50.34 ± 17.06 ）u/ml,respectively. The difference was also statistically significant（P〈0. 05）. Conclusion TAM,CEA,CA72-4 united detec tion can be used as evaluation index of chemotherapy curative effect for earlier forecast.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2013年第1期65-67,共3页
Cancer Research on Prevention and Treatment
