摘要
目的探讨核糖体蛋白S6(RPS6)基因多态性与汉族人原发性卵巢功能不全(POI)易感性的关系。方法采用基质辅助激光解析质谱仪检测148例POI患者和226例正常对照者RPS6基因rs2277151位点的基因型,使用SPSS13.0软件对所得数据进行统计分析。结果该位点基因型和等位基因频率在病例组和对照组间的差异均无统计学意义。结论 RPS6基因多态性与汉族人POI易感性不相关。
Objective To investigate the relationship between the polymorphism of ribosomal protein （RPS6） gene and susceptibility of primary ovarian insufficiency （POI） in Chinese Han population. Methods We used the ma- trix-assisted laser desorption/ionization time-of-flight mass spectrometry to genotype one single nucleotide polymor- phism （rs2277151） of RPS6 gene in 148 cases and 226 controls, then used the SPSS 13.0 software to analyze the data. Results There was no significant difference in genotype and allele frequencies between cases and controls of rs2277151 in Chinese Han population. Conclusion Our study suggests that the polymorphism of RPS6 gene may not associate with susceptibility of primary ovarian insufficiency in Chinese Han population.
出处
《安徽医科大学学报》
CAS
北大核心
2013年第2期149-151,共3页
Acta Universitatis Medicinalis Anhui
基金
国家"973"项目(编号:2012CB944704)
国家自然科学基金(编号:30973197)
