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新德里金属β-内酰胺酶的研究进展 被引量:2

Progress in research on New Delhi metallo-lactamase-1
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摘要 新德里金属β-内酰胺酶-1(New Delhi metallo-lactamase-1,NDM-1)是新近发现的由细菌产生的一种能够水解碳青霉烯类的金属β-内酰胺酶。NDM-1具有强大的水解作用,几乎能抵抗目前使用的所有抗生素,已严重威胁人类健康。本文对NDM-1携带菌的流行现状、NDM-1的基因排布特点、蛋白结构特点及酶活性中心的最新研究进展作一综述。 A new metallo-lactamase,New Delhi metallo-lactamase-1(NDM-1),has been discovered,which can hydrolyze carbapenems.With a high hydrolytic activity,NDM-1 is resistant to almost all the antibiotics,which has been a threat to the health of humans.This paper reviews the prevalence of bacteria carrying NDM-1 as well as the gene arrangement,protein structure and enzyme activity site of NDM-1.
出处 《中国生物制品学杂志》 CAS CSCD 2013年第1期139-143,共5页 Chinese Journal of Biologicals
关键词 新德里金属β-内酰胺酶 耐药性 流行病学 基因排布 蛋白结构 New Delhi metallo-lactamase Drug-resistance Epidemiology Gene arrangement Protein structure
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