摘要
目的观察加减薯蓣丸对非痴呆血管性认知功能障碍(vascular cognitive impairment no dementia,VCIND)的早期干预效果。方法 VCIND患者随机分为治疗组(43例)和对照组(33例),在针对血管危险因素治疗的基础上,治疗组加用加减薯蓣丸,对照组加用盐酸多奈哌齐,疗程16周,观察患者用药前后简易智能精神状态检查量表(mini-mental state examination,MMSE)、蒙特利尔认知评估量表(Montreal cognitiv eassessment,MOCA)及中医痴呆证候量表评分。结果与本组治疗前比较,两组治疗后MMSE、MO-CA评分均明显增加(P<0.01),治疗前后两组比较,差异无统计学意义(P>0.05);与本组治疗前比较,治疗后治疗组中医痴呆证候量表评分显著减少(P<0.01),而对照组治疗前后比较差异无统计学意义(P>0.05),两组治疗后中医痴呆证候量表评分比较,差异有统计学意义(P<0.01)。结论加减薯蓣丸可以有效干预VCIND的病程进展。
Objective To observe early intervention effects of Modified Shuyu Pill （MSP）on vascular cognitive impairment no dementia （VCIND）. Methods Totally 100 patients VCIND were randomly assigned to the treatment group （43 cases）and the control group （33 cases）. On the basis of the treat- ment targeting risk factors of blood vessels, patients in the treatment group were treated by MSP, while those in the control group were treated by donepezil hydrochloride. The therapeutic course was 16 weeks. The neuropsychological scales [ mini-mental state examination （MMSE）and Montreal cognitive assessment （MOCA）score] and Chinese medicine dementia syndromes scales were observed before and after treatment. Results The MMSE and MOCA score of the two groups increased when compared with the same group before treatment （ P 〈0.01 ） .But there was no statistical difference in MMSE or MOCA score after treatment between the two groups （P 〉0.05）. The Chinese medicine dementia syndromes scales significantly decreased in the treatment group when compared with before treatment （P 〈0.01 ）. But there was no statistical difference in Chinese medicine dementia syndromes scales in the control group between before and after treatment （P 〉0.05）. There was statistical difference in Chinese medicine dementia syndromes scales after treatment between the two groups （P 〈 0.01 ）. Conclusion MSP could effectively intervene the progress of VCIND.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2013年第1期27-30,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
2009-2010年度湖北省卫生厅科研重点资助项目(No.JX4A04)
关键词
加减薯蓣丸
非痴呆血管性认知功能障碍
早期干预
Modified Shuyu Pill
vascular cognitive impairment no dementia
early intervention
