摘要
目的:合成磺胺嘧啶铜并建立其质量控制方法。方法:利用磺胺嘧啶与硫酸铜发生反应合成磺胺嘧啶铜;采用质谱、红外光谱和元素分析对产物进行结构、理化鉴别和确证,采用滴定法测定其含量。结果:合成物产率为93%,经质谱、红外光谱和元素分析证实合成物为磺胺嘧啶铜,理化鉴别反应均为阳性;含量测定方法学考察中平均回收率为97.73%(RSD=0.33%,n=9)。结论:本品合成方法简易可行,质量控制方法准确、可靠。
OBJECTIVE： To synthesize sulfadiazine copper and to establish the method for quality control of it. METHODS： Sulfadiazine copper was synthesized by using sulfadiazine and copper sulfate. The structure, physical and chemical properties were identified and confirmed by mass spectrum, IR spectrum and element analysis; titration method was used for the content determina- tion of sulfadiazine copper. RESULTS： The yield of compounds was 93%. The compounds were proved to be sulfadiazine copper by mass spectrum, IR spectrum and element analysis. The physical and chemical properties were positive. The average method re- coveries were 97.73% （RSD=0.33% ,n=9）. CONCLUSIONS： The method is simple and feasible, and it is accurate and reliable for quality control
出处
《中国药房》
CAS
CSCD
2013年第5期448-450,共3页
China Pharmacy
关键词
磺胺嘧啶铜
合成
鉴别
含量测定
质量控制
Sulfadiazine copper
Synthesis
Identification
Content determination
Quality control
