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关于依托咪酯的争论与进展 被引量:4

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摘要 在静脉全身麻醉诱导药物中,依托咪酯是唯一的咪唑类药物,而且只需一次给药就可获得满意的效果。然而它所产生的毒性反应在麻醉药物中也是独特的,即抑制肾上腺皮质功能,这种抑制作用甚至比它所产生的镇静催眠作用还要持久,从而减少危重患者的存活率。依托咪酯在对中枢神经系统的麻醉作用中其分子靶点是特异性GABA受体的A亚型,在这些跨膜转运的蛋白质域中发现了形成依托咪酯结合位点的氨基酸。依托咪,
作者 冯璐
出处 《吉林医学》 CAS 2013年第2期325-326,共2页 Jilin Medical Journal
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