摘要
目的心型脂肪酸结合蛋白对于急性心肌梗死早期诊断的意义。方法 52例因急性胸痛入院的患者经心电图及临床病史怀疑AMI,在胸痛症状出现后3 h、3～6 h和6～12 h抽血定量检测H-FABP并同时检测肌钙蛋白,绘制H-FABP和肌钙蛋白在不同时间段的ROC曲线,计算其曲线下面积(AUC),比较各自的敏感度和特异度。结果 H-FABP和肌钙蛋白在胸痛后3 h、3～6 h和6～12 h的敏感性分别为0.931 vs 0.533,0.946 vs 0.933和0.900vs 0.967;而特异性为0.867 vs 0.818、0.929 vs 0.918和0.846 vs 0.912。结论 H-FABP对6小时内发生的急性心肌梗死较cTnT具有更高的敏感度和特异度。
Objective To evaluate the early diagnostic and prognostic value of heart-type fatty acid-binding protein for acute myocardial infarction. Methods Fifty-two patients with acute chest pain were enrolled in this study, they were consid- ered mostly like the AMI according to the ECG and clinical history. Then the blood samples were obtained especially for H-FABP, cTnT within the third, sixth, and twelfth hours, and draw the receiver operator characteristic curve. Evaluation of the sensitivity and specificity of the H-FABP and cTnT was done according to the area under the ROC. Results The sensitivity and specifici- ty of the H-FABP and cTnT were respectively 0. 931 vs 0. 533, 0. 946 vs 0. 933, 0. 900 vs 0. 967 and 0. 867 vs 0. 818, 0. 929 vs 0. 918, 0. 846 vs 0. 912. Conclusion H-FABP was more specificity and sensitivity than cTnT at the early hours of myo- cardial injury particularly within 6 hours after the chest pain.
出处
《广州医药》
2013年第1期19-20,26,共3页
Guangzhou Medical Journal
关键词
心型脂肪酸结合蛋白
急性心肌梗死
肌钙蛋白
Heart-type fatty acid-binding protein
Acute myocardial infraction
Cardiac troponin
