摘要
用限制性内切酶对我国长春等5个地区引起婴幼儿肺炎的3型病毒(Ad_3)140株进行基因组型分析、分子流行病学特点及与临床致病的研究结果表明,我国5个地区14年间Ad_3有3个基因组型。我们命名为Ad_3Ⅰ、Ad_3Ⅱ和Ad_3Ⅲ。Ad_3Ⅰ是流行的优势基因组型。并证实一种优势基因组型是多种疾病的致病原。Ad_3流行高峰和年代出现变异株其毒力增强,通过与Ad_7优势基因型比较,揭示了3.7型腺病毒临床差异的实质。
We analysed 140 strains of adenovirus type 3 (Ad3) by using restriction endoneuclease BgL Ⅱ and BamH Ⅰ during 14 years (1976-1989) in Changchun, Shenyang, Beijing, Shanghai and Nangjing. Three genomes were identified in these five areas, and named Ad3 Ⅰ , Ad3 Ⅱ and Ad3 Ⅲ . Ad3 Ⅰ was the dominant genome in Ad3. During the period ot epidemic high peak, there would be variant strains of Ad3 with stronger pathogenicity and virulence. Through comparison , essentially, the clinical difference between adenovirus 3 and 7 was revealed on the molecular levels
出处
《白求恩医科大学学报》
CSCD
1991年第6期573-575,共3页
Journal of Norman Bethune University of Medical Science
