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依托咪酯作用机制的研究和临床应用现状 被引量:17

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摘要 依托咪酯是咪唑类衍生的非巴比妥类短效静脉全身麻醉药,有较好的镇静作用,无镇痛作用,尤其适用于休克、有心血管危险因素、血流动力学不稳定、低血容量及气道高反性患者的全麻诱导。但其对肾上腺皮质功能的抑制作用不同程度上限制了其在临床上的应用,尤其在对长时间镇静和病情危重免疫力低下患者的应用中倍受争议。作为一种优势显著,又有应用限制,并具备研究和开发潜力的静脉全身麻醉药,依托咪酯越来越受到研究者的关注,对其的研究也逐渐深入和全面。
出处 《山东医药》 CAS 2013年第1期95-97,共3页 Shandong Medical Journal
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  • 1Li GD, Chiara DC, Cohen JB. Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors[J]. J Biol Chem, 2009,284(18) :11771-11775.
  • 2Martin LJ, Oh GH, Orser BA. Etomidate targets alpha5 gamma- aminobutyric acid subtype A receptors toregulate synaptic plasticity and memory blockade [ J ]. Anesthesiology, 2009,111 ( 5 ) : 1025- 1035.
  • 3Forman SA. Clinical and molecular pharmacology of etomidate[J]. Anesthesiology, 2011,114 (3) :695-707.
  • 4Shirozu K, Akata T, Yoshino J, et al. The mechanisms of the direct action of etomidate on vascular reactivity inrat mesenteric resistance arteries[ J]. Anesth Analg, 2009,108 (2) :496-507.
  • 5Hwang JY, Kim JH, Oh AY, et al. A comparison of midazolam with remifentanil for the prevention of myoclonic movements following eto- midate injection[J]. J Int Med Res, 2008,36(1) :17-22.
  • 6Zhang X, Xiong J, Jiao Y, et al. Involvement of mitochondrial ATP-sensitive potassium channels inetomidate preconditioning-in- duced protection in huma:, myeloid HL-60 cells [ J ]. Environ Toxi- col Pharmacol, 2010,29 (3) : 320-322.
  • 7Murray H, Marik PE. Etomidate for endotracheal intubation in sep- sis : acknowledging the good while accepting the bad [ J ]. Chest, 2005,127 (3) :707-709.
  • 8Daniell H. Opioid and benzodiazepine contributions to etomidate-as- sociated adrenal insufficiency [ J ]. Intensive Care Med, 2008,34 (11) :2117-2118.
  • 9Warner KJ, Cuschieri J, Jurkovich GJ, et al. Single-dose etomidate for rapid sequence intubation may impact outcomeafter severe injury [J]. J Trauma, 2009,67( 1 ) :45-50.
  • 10Herrera-Peco I, Wix Ramos R, Dominguez-Gadea L, et al. What do changes in brain perfusion induced by etomidate suggest about epilepsy in human patients[ J]. Epilepsy Res Treat, 2010:654265.

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