摘要
目的:研究β-环糊精对喹诺酮类抗生素药品抑菌性的中和作用,建立喹诺酮类抗生素药品微生物限度检查方法。方法:以β-环糊精为中和剂,采用薄膜过滤法对喹诺酮类抗生素药品进行微生物限度方法学研究。结果:β-环糊精对喹诺酮类抗生素药品的抑菌性有较好的中和作用,经过实验,5株验证菌回收率均在70%以上。结论:β-环糊精可作为消除喹诺酮类抗生素药品抑菌活性的中和剂,解决该类药品微生物限度检查方法建立困难问题。
Objective ： To study the neutralization effect of β - cyclodextrin against the bacteria restraint of quinolo- nes antibiotics, and establish a microbial limit test method for quinolones antibiotics. Methods：The microbial limit test method of quinolones antibiotics was established using β- cyelodextrin as the neutralizing agent and utilize fil- tration method. Results：The method can pass the validation test of Chinese Pharmacopoeia（ ChP） 2010 version, the rates of recovery of five validation strains were all above 70%. Conclusion ：β - Cyclodextrin can neutralize the anti- septic effect of quinolones and the established method can be applied in microbial limit test for quinolones antibiot- ics preparation control.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2013年第1期18-21,29,共5页
Chinese Journal of Pharmaceutical Analysis
关键词
抗菌剂
喹诺酮类抗生素
Β-环糊精
中和剂
包埋
薄膜过滤法
抑菌性
微生物限度检查
Key words： antibacterial agent
quinolones antibiotics
β - cyclodextrin
neutralizing agent
inclusion
membrane -filter
antimicrobial effect
microbial limit test method
