摘要
目的：了解ICU内中心静脉导管相关性血流感染（CRBSI）病原菌的分布特点及其耐药性，以指导临床合理用药。方法：回顾性分析2009年1月至2011年12月ICU内CRBSI患者病原菌分布和药物敏感试验资料，比较排位前7位细菌的耐药特征。结果：67例CRBSI患者共检出81株病原菌，其中革兰阳性（G＇）菌40株，占49.2%;革兰阴性（G^-）菌38株，占46.9%;真菌3株，占3.7%,引起CRBSI的主要病原菌依次为凝固菌阴性葡萄球菌（27株，33.3%），鲍曼不动杆菌（12株，14.8%），肺炎克雷伯菌（9株，11.1%），金黄色葡萄球菌（8株，9.9%），铜绿假单胞菌（7株，8.6%），大肠埃希菌（6株，7.4%），G^＋菌中对碳青霉烯菌类最为敏感。结论：近3年来ICU内CRBSI患者病原菌以表皮葡萄球菌及鲍曼不动杆菌为主，并且鲍曼不动杆菌耐药率较高。
Objective： To learn the features and drug resistance of pathogens in ICU central venous catheter related bloodstream infections （CRBSI） and to guide rational drug use. Methods： Through retrospective analysis of clinical data of pathogenic bacteria distribution and drug sensitive in ICU CRBSI patients from January, 2009 to December, 20 11, to compare the drug resistance of the former 7 strains of bacteria. Results： There are totally 81 strains of pathogens, among which 40 strains of Gram-positive bacteria （G＋）, accounting for 49.2%; 38 Gram-negative bacteria （G） with 46.9%; 3 fungi is 3.7%. The main pathogenic bacteria that cause CRBSI are coagulase negative staphylococcus （27 strains, 33.3%）, Acinetobacter baumanii （12 strains, 14.8%）, pneumonia gram Reber fungus （9 trains, 11.1%）, Staphylococcus aureus （8 stains, 9.9%）, Pseudomonas aeruginosa （7 strains, 8.6%）, E. coli （6 strains, 7.4%）. G^＋ bacteria were mainly of Staphylococcus epidermidis, while G bacteria were mainly of Acinetobacter baumanii. The resistance rate to vancomycin of G＋ bacteria was 0, and G^- bacteria was most sensitive to carbapenemases. Conclusion： In recent three years, the pathogens of ICU CRBSI patients were mainly of Staphylococcus epidermidis and Acinetobacter baumanii, and Acinetobacter baumanii were of high drug resistance.
出处
《麻醉与监护论坛》
2012年第6期452-454,共3页
Forum of Anesthesia and Monitoring
关键词
相关性感染
血培养
细菌耐药
重症加强治疗病房
Related infection
Blood cultures
Antibiotic resistance
Intensive care unit （ICU）
