摘要
目的:探讨老年2型糖尿病(DM2)患者血清可溶性单核-巨噬细胞血红蛋白清道夫受体(sCD163)和抗氧化型低密度脂蛋白抗体(oxLDL-Ab)与大血管病变的关系。方法:测定189例DM2患者及50例正常对照者sCD163和oxLDL-Ab水平,189例DM2患者分为大血管病变组(120例)与无大血管病变组(69例),比较三组间sCD163和oxLDL-Ab水平,并进行相关性分析。结果:与正常对照组比较DM2组sCD163与oxLDL-Ab水平较高、DM合并大血管病变组sCD163与oxLDL-Ab水平高于DM无血管病变组,各组间有显著性差异(P<0.05,P<0.05),且sCD163与oxLDL-Ab水平呈正相关(r=0.45,P<0.05)。结论:sCD163与oxLDL-Ab与DM2大血管病变的发生发展密切相关,且联检可对早期动脉硬化的诊断具有重要的指导意义。
Objective To explore the elderly type 2 diabetes mellitus （DM2） patients on serum soluble macrophage hemoglobin scavenger receptor （sCD163） and oxidized low density lipoprotein antibody （oxLDL-Ab） and its relationship with macrovascular diseases. Methods sCD163 and oxLDL-Ab were measured in 189 diabetics and 50 healthy controls 189 patients with diabetes mellitus, di- vided into large vascular lesion group （ 120 cases） and no major vascular lesion group （69 cases）, a comparison of three groups with sCD163 and oxLDL-Ab level, and the analysis of were made correlation. Results Compared to normal group, the diabetes group sCD163and oxLDL-Ab levels were higher, DM with large blood vessel lesion group sCD163and oxLDL-Ab levels higher than those in DM without vascular lesion group, each group manifested statistical significance （P 〈0.05 ,P 〈0.05）, and sCD163and oxLDL-Ab levels are positively correlated （r = 0.45, P 〈 0.05）. Conclusion sCD163and oxLDL-Ab and diabetic macrovascular disease occurrence is closely related to the development and combined detection of early arteriosclerosis diagnosis provides important guiding significance.
出处
《放射免疫学杂志》
CAS
2013年第1期71-74,共4页
Journal of Radioimmanology
