摘要
目的:探讨原发性高血压患者血浆ET-1水平与脂质过氧化的关系。方法:分别应用放免法和生化法对33例高血压患者进行血浆ET-1、丙二醛(MDA)、超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)含量测定,并与35名正常健康人作比较。结果:原发性高血压患者血浆ET-1、MDA水平非常显著地高于正常人组(P<0.01),而血清SOD、GSH-PX水平非常显著地低于正常人组(P<0.01)。相关分析显示,血清SOD、GSH-PX水平与MDA水平呈显著负相关(r=-0.4218、-0.4011,P<0.01)。结论:原发性高血压患者血清SOD、GSH-PX水平的降低与活性代谢紊乱密切相关。
Objective To assess the relationship between the plasma ET-1 level and lipid peroxidation in patients with primary hypertension. Methods Plasma ET-1 （with ELISA）, serum MDA, SOD and GSH-PX （with biochemistry） levels were measured in 33 patients with primary hypertension and 35 normal controls. Results Plasma ET-1, MDA levels were significantly higher in patients with primary hypertension than those in controls（ P 〈 0.01 ）, but serum SOD, GSH-PX levels were obviously lower（ P 〈 0.01 ）. Serum SOD, GSH-PX levels were negatively correlated with MDA level （ r = -0.4218,-0.4011,P 〈 0.01 ）. Conclusion Decreases of serum SOD, GSH-PX levels were closely related with the disorder of active metabolism in patients with primary hypertension.
出处
《放射免疫学杂志》
CAS
2013年第1期25-27,共3页
Journal of Radioimmanology
关键词
原发性高血压
内皮素
丙二醛
超氧化物岐化酶
谷胱甘肽过氧化物酶
primary hypertension, endothelin-1 （ ET-1 ）, malondialdohyde （ MDA）, superoxide dismutase （SOD）, glutathione peroxidase （GSH-PX）
