摘要
目的:基于发表的丹寿汤文献数据,采用模型化及模拟化进行再分析,提取更多信息,以期优化配伍方案。方法:原文丹寿汤以正交t值L12设计,1水平为"使用",2水平为"未使用",胚胎吸收率为药效指标。采用正交模拟法结合非线性混合模型结合,定量评价各组分在复方中相对重要程度和相互作用,模型评价采用4种视图进行综合评价。结果:丹寿汤组方中,全方呈现药效相加作用;主要药效学组分重要程度依次为菟丝子(A)、丹参(E)、续断(B)(P<0.05)。理论上不同配伍中,最佳组分配伍为ABCEF,4种视图评价模型表明所建模型预测能力较好。结论:采用正交模拟法结合非线性混合模型定量分析复方配伍数据,可获大量组方定量设计信息。
Objective： To explore the application and rationality of the nonlinear mixed effect model （NONMEM） in quantitative analysis for finding an optimal combination based on the public published data. Method： Based on the original data of Danshou tang formulation in the published literature, an orthogonal design, with l-level （used） and 2-1eve1 （not used） in L12, was used to assign experimental groups of the combinations of components, the embryos absorption rate was the primary endpoint, mathematical model was build up with the nonlinear mixed effect model （NONMEM） for the experiment. The importance and effectiveness of each component were analyzed in combinations and the bias was evaluated by 4 charts. Result： The whole formulation of Danshou tang showed addition action, the contribution to combined effect of each component in order was A, E, B （P 〈 0.05）. The best combination would be the ABCEF theoretically, and 4 diagrams revealed the reliability and the stability of the model. Conclusion： More information about prescription compatibility can be obtained by the orthogonal simulation method with NONMEM.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第2期339-343,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家科技支撑计划项目(2008BAI51B03)
上海高校青年培养资助计划(ZZszy12046)
关键词
丹寿汤
药物相互作用
定量评价
Danshou tang
drug interactions
quantitative evaluation
