摘要
目的探索偏头痛中西医临床诊疗的规律。方法应用中国生物医学文献服务系统,收集治疗偏头痛的文献数据,采用基于敏感关键词频数统计的数据分层算法,并结合原文献回溯、人工阅读分析等方法,挖掘有关偏头痛证候、症状、中药、中成药以及西药联用的规律,并通过一维频次表及二维的网络图对结果进行展示。结果共检索到偏头痛文献7 921篇。文本挖掘结果显示,肝阳上亢、肝气郁结、气虚血瘀等是偏头痛主要的中医证型,核心症状以头痛、呕吐、恶心、头晕、畏光等为主,川芎、天麻、丹参、柴胡、当归、白芍、白芷等是中药治疗的核心药物,偏头痛常用的中成药以养血清脑颗粒、头痛宁胶囊、正天丸等为主;西药以氟桂利嗪、尼莫地平、阿司匹林等最为常用,中成药与西药联用最常用的方案是养血清脑颗粒联合尼莫地平。结论文本挖掘得到的偏头痛证候、症状、中药、中成药以及中成药与西药的联用结果有助于规范、全面的认识本病,对临床实际有一定的参考意义。
Objective To analyze the regularity of clinical medication in the treatment of migraine with text mining approach.Methods The data set of migraine was downloaded from Chinese BioMedical Literature Database（CBM）.Rules of TCM pattern,symptoms,Chinese herbal medicines（CHM）,Chinese patent medicines（CPM） and western medicines on migraine were mined out by data slicing algorithm,the results were demonstrated in both frequency tables and two-dimension based network.Results A total of 7 921 literatures were searched.The main syndrome classification in TCM of migraine included liver-yang hyperactivity syndrome,stagnation of liver qi syndrome and qi deficiency to blood stasis syndrome,et al.The core symptoms of migraine included headache,vomit,nausea,swirl,photophobia,et al.Traditional Chinese medicine for migraine contained Chuanxiong,Tianma,Danshen,Chaihu,Danggui,Baishao and Baizhi,et al.For Chinese patent medicine,Yangxueqingnao granule,Toutongning capsule and Zhengtian pill were used in treating migraine.In western medicine,flunarizine,nimodipine and aspirin were used frequently.For the integrated treatment of TCM and western medicine,the combination of Yangxueqingnao granule and nimodipine was most commonly used.Conclusion Text mining approach provides a novel method in the summary of treatment rules on migraine in both TCM and western medicine.To some extent,the migraine results from texting mining has significance for clinical practice.
出处
《中国中医药信息杂志》
CAS
CSCD
2013年第2期30-33,共4页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金杰出青年项目(30825047)
中国中医科学院基本科研业务费自主选题(Z0195
Z0114)
关键词
文本挖掘
数据分层算法
偏头痛
证候
症状
中药
西药
text mining
data slicing algorithm
migraine
TCM syndrome
symptom
Chinese medicine
western medicine
