摘要
本文观察了40例健康人,28例胃癌,26例球部溃疡,19例胃溃疡及9例胃溃疡伴不典型增生病人的IL—2活性及NK细胞活性。其中胃癌病人IL—2及NK活性最低,与健康对照组比较,P<0.0005;胃溃疡伴不典型增生病人的IL—2活性及NK活性,虽然高于胃癌病人,但却显著低于健康人,统计学有意义。将正常人和病人的PBMC分别用IL—2处理后,观察IL—2对NK细胞的调节作用,IL—2对正常人及病人的NK细胞活性均有促进作用,但未能使NK活性显著低下的胃癌病人的NK活性恢复至正常人水平。
The IL-2 activity and the NK cell activity of the peripheral blood in 40 normal donors and 85 patients (28 with gastric cancer, 26 with duodenal ulcer, 22 with gastric ulcer and 9 suffering fron gastric ulcer with atypical hyperplasia) were determined. The activity of IL-2 and NK cells in patients with gastrie cancer were the lowest in all the patients with gastropathy and were significantly lower than those of the normal subjects (P<0.0005). Though the activity of IL-2 and NK cells in patients suffering from gastric ulcer with atypical hyperplasia were higher than those with gastric cancer, but still significantly lower than those of the normal subjects. The NK cell activity of both the normal subjects and the gastropathic patients was enhanced when mononuclear cells of the peripheral blood had been pre-treated with IL-2 .However, the lowered NK cell activity in patients with gastric cancer could not be restored to the normal level.
出处
《白求恩医科大学学报》
CSCD
1991年第2期148-151,共4页
Journal of Norman Bethune University of Medical Science
关键词
胃癌
溃疡
白细胞介素Ⅱ
NK
Interleukin 2 Natural killer cells Gastric cancer Peptic ulcer Atypical hyperplasia
