摘要
在微波辐射条件下,5-苯基-1H-四唑与对苯甲酰氯反应合成2-苯基-5-(4-(5-苯基-1,3,4-噁二唑基)苯基)-1,3,4-噁二唑。考察了微波功率、反应时间和加入吡啶的量对反应的影响。结果表明:462 W微波功率,反应时间10 min,吡啶量0.5 mL时,反应条件最优化,产率为81.6%。相同投料的情况下,传统的加热方法 (100℃,反应12 h)的产率仅为15.5%。
2 - phenyl - 5 - （4 - （5 - phenyl - 1,3,4 - oxadiazol - 2 - yl） phenyl） - 1,3,4 - oxadiazole was synthe- sized by 5 - phenyl - 1H - tetrazole and terephthaloyl chloride under microwave irradiation. The factors including micro- wave power, time of irradiation and the amount of pyridine were investigated. The experimental results indicated the yield was 81.6% under conditions of microwave power 462 W, irradiation time 10 min, and pyridine 0.5 mL. Under the same conditions, compared to the conventional method of temperature 100℃ and reaction time 12 h, the yield was only 15.5%.
出处
《广州化工》
CAS
2013年第1期90-91,112,共3页
GuangZhou Chemical Industry
