摘要
目的探讨5-氨基酮戊酸光动力疗法(ALA-PDT)预防尖锐湿疣复发的临床疗效。方法选择2011年～2012年于我院就诊的80例尖锐湿疣患者,随机分为实验组40人和对照组40人。2组均采用CO2激光祛除疣体。待患者创面愈合后,对照组不做特殊处理,仅2w随访1次,共随访24w。实验组在患者创面愈合后,采用ALA-PDT处理原疣体,2w随访1次,共随访24w。结果对照组非尿道CA26例,治愈17例,复发9例,复发率34.61%,尿道CA14例,治愈7例,复发7例,复发率50%,总复发率为40%。实验组非尿道CA25例,治愈22例,复发3例,复发率12%,尿道CA15例,治愈13例,复发2例,复发率13.33%,总复发率12.5%。实验组总复发率低于对照组,差异有统计学意义(P<0.05)。对照组平均复发周期为11.75w,实验组平均复发时间为15.6w,实验组复发周期高于对照组,差异有统计学意义(P<0.05)。结论采用5-氨基酮戊酸光动力疗法处理尖锐湿疣患者,可以显著降低复发率,延长复发时间,适合临床长期推广应用。
Objective To observe clinical effect of ALA-PDT in preventing recurrence of Condylomata acuminate. Methods During April 2011 and April 2012 in our hospital, 80 cases were randomly divided into two groups. Two groups were both cured with CO2 laser. Control group included 40 cases without ALA-PDT and test group included 40 cases used ALA-PDT. Results The overall recurrence rate of control group was 40% and the test group was 12. 5% . The overall recurrence rate of test group was lower than control group, the difference was statistically significant（P〈0. 05）. The recurrence time of control was 11. 75w and test group was 15. 6w. The recurrence time of test group was higher than control group, the difference was statistically significant（P〈0.05）. Conclusions To use ALA-PDT to prevent the recurrence of CA can significantly cut down the recurrence rate and prolong the recurrence time. It has a significant clinical effect so that can he popularized.
出处
《成都医学院学报》
CAS
2012年第4期612-614,共3页
Journal of Chengdu Medical College
基金
中国高校医学期刊临床专项资金(NO:11221618)
